Innate immune deficiency of extremely premature neonates can be reversed by interferon-γ

Tissières, Pierre; Ochoda, Agnieszka; Dunn-Siegrist, Irène; Drifte Roduit, Geneviève Sophie; Morales, Michel Ange; Pfister, Riccardo; Berner, Michel; Pugin, Jérôme

doi:10.1371/journal.pone.0032863

Scientific article

Open access

English

Innate immune deficiency of extremely premature neonates can be reversed by interferon-γ

ContributorsTissières, Pierre; Ochoda, Agnieszka; Dunn-Siegrist, Irène; Drifte Roduit, Geneviève Sophie; Morales, Michel Ange; Pfister, Riccardo; Berner, Michel; Pugin, Jérôme

Published inPloS one, vol. 7, no. 3, e32863

Publication date2012

Abstract

Bacterial sepsis is a major threat in neonates born prematurely, and is associated with elevated morbidity and mortality. Little is known on the innate immune response to bacteria among extremely premature infants.

Keywords

Body Weight
Cell Line
Female
Fetal Blood/cytology/immunology
Flow Cytometry
Gestational Age
Humans
Immunity, Innate/immunology
Infant, Extremely Low Birth Weight/immunology
Infant, Newborn
Infant, Premature/immunology
Interferon-gamma/therapeutic use
Leukocytes/metabolism
Male
Phagocytosis/physiology
Pregnancy
Receptors, Immunologic/metabolism
Sepsis/drug therapy/immunology
Statistics, Nonparametric

Affiliation

Research group

Citation (ISO format)

TISSIÈRES, Pierre et al. Innate immune deficiency of extremely premature neonates can be reversed by interferon-γ. In: PloS one, 2012, vol. 7, n° 3, p. e32863. doi: 10.1371/journal.pone.0032863

Article (Published version)

CC BY

Identifiers

PID : unige:31686
DOI : 10.1371/journal.pone.0032863
PMID : 22427899

ISSN of the journal1932-6203

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Innate immune deficiency of extremely premature neonates can be reversed by interferon-γ

Bacterial sepsis is a major threat in neonates born prematurely, and is associated with elevated morbidity and mortality. Little is known on the innate immune response to bacteria among extremely premature infants.

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