Overexpression of endothelin-1 and endothelin receptors in the pulmonary arteries of failed Fontan patients

Ishida, Hidekazu; Kogaki, Shigetoyo; Ichimori, Hiroaki; Narita, Jun; Nawa, Nobutoshi; Ueno, Takayoshi; Takahashi, Kunihiko; Kayatani, Futoshi; Kishimoto, Hidehumi; Nakayama, Masahiro; Sawa, Yoshiki; Beghetti, Maurice; Ozono, Keiichi

doi:10.1016/j.ijcard.2011.02.021

Scientific article

English

Overexpression of endothelin-1 and endothelin receptors in the pulmonary arteries of failed Fontan patients

ContributorsIshida, Hidekazu; Kogaki, Shigetoyo; Ichimori, Hiroaki; Narita, Jun; Nawa, Nobutoshi; Ueno, Takayoshi; Takahashi, Kunihiko; Kayatani, Futoshi; Kishimoto, Hidehumi; Nakayama, Masahiro; Sawa, Yoshiki; Beghetti, Maurice; Ozono, Keiichi

Published inInternational journal of cardiology, vol. 159, no. 1, p. 34-39

Publication date2012

Abstract

Endothelin-1 (ET-1), a potent vasoconstrictor, is considered to be implicated in failing Fontan circulation, however the expressions of ET-1 and endothelin receptor type A (ET(A)R) and type B (ET(B)R) in the pulmonary arteries of failed Fontan patients were not elucidated.

Keywords

Adolescent
Child
Child, Preschool
Endothelin-1/biosynthesis/genetics
Female
Follow-Up Studies
Fontan Procedure/trends
Gene Expression Regulation
Humans
Male
Pulmonary Artery/metabolism/pathology/surgery
Receptor, Endothelin A/biosynthesis/genetics
Receptor, Endothelin B/biosynthesis/genetics
Treatment Failure

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research groups

L'hypertension pulmonaire (pédiatrie) (228)

Citation (ISO format)

ISHIDA, Hidekazu et al. Overexpression of endothelin-1 and endothelin receptors in the pulmonary arteries of failed Fontan patients. In: International journal of cardiology, 2012, vol. 159, n° 1, p. 34–39. doi: 10.1016/j.ijcard.2011.02.021

Article (Published version)

Identifiers

PID : unige:31659
DOI : 10.1016/j.ijcard.2011.02.021
PMID : 21356562

Journal ISSN0167-5273

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Overexpression of endothelin-1 and endothelin receptors in the pulmonary arteries of failed Fontan patients

Endothelin-1 (ET-1), a potent vasoconstrictor, is considered to be implicated in failing Fontan circulation, however the expressions of ET-1 and endothelin receptor type A (ET(A)R) and type B (ET(B)R) in the pulmonary arteries of failed Fontan patients were not elucidated.

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