Long-lasting protection of activity of nucleoside reverse transcriptase inhibitors and protease inhibitors (PIs) by boosted PI containing regimens

Scherrer, Alexandra U; Böni, Jürg; Yerly Ferrillo, Sabine; Klimkait, Thomas; Aubert, Vincent; Fürrer, Hansjakob; Calmy, Alexandra; Cavassini, Matthias; Elzi, Luigia; Vernazza, Pietro L; Bernasconi, Enos; Ledergerber, Bruno; Günthard, Huldrych F

doi:10.1371/journal.pone.0050307

Scientific article

Open access

English

Long-lasting protection of activity of nucleoside reverse transcriptase inhibitors and protease inhibitors (PIs) by boosted PI containing regimens

ContributorsScherrer, Alexandra U; Böni, Jürg; Yerly Ferrillo, Sabine; Klimkait, Thomas; Aubert, Vincent; Fürrer, Hansjakob; Calmy, Alexandra

; Cavassini, Matthias; Elzi, Luigia; Vernazza, Pietro L; Bernasconi, Enos; Ledergerber, Bruno; Günthard, Huldrych F

Published inPloS one, vol. 7, no. 11, e50307

Publication date2012

Abstract

The accumulation of mutations after long-lasting exposure to a failing combination antiretroviral therapy (cART) is problematic and severely reduces the options for further successful treatments.

Keywords

Adult
Anti-HIV Agents/administration & dosage/therapeutic use
Antiretroviral Therapy, Highly Active
Cohort Studies
Drug Resistance, Viral/genetics
Female
Genotype
HIV Infections/drug therapy/virology
HIV-1/drug effects/genetics
Humans
Male
Middle Aged
Mutation
Protease Inhibitors/administration & dosage/therapeutic use
Reverse Transcriptase Inhibitors/administration & dosage/therapeutic use
Risk Factors
Time Factors
Treatment Failure
Viral Load

Affiliation

Faculté de médecine / Section de médecine clinique / Département de médecine

Research group

VIH/SIDA (930)

Citation (ISO format)

SCHERRER, Alexandra U et al. Long-lasting protection of activity of nucleoside reverse transcriptase inhibitors and protease inhibitors (PIs) by boosted PI containing regimens. In: PloS one, 2012, vol. 7, n° 11, p. e50307. doi: 10.1371/journal.pone.0050307