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Doctoral thesis
English

Vesicular glutamate transporter 3 expressing neurons gate output pathways of the mouse olfactory bulb

ContributorsTatti, Roberta
Defense date2013-10-30
Abstract

In sensory systems, peripheral organs convey sensory inputs to relay networks where information is shaped by local microcircuits before being transmitted to cortical areas. In the olfactory system, odorants evoke specific patterns of sensory neurons activity which are transmitted to output neurons in olfactory bulb glomeruli. How sensory information is transferred and shaped at this level remains still unclear. Here, using mouse genetics, 2-photon microscopy, electrophysiology and optogenetics, we identified a novel population of glutamatergic neurons (VGLUT3+) in the glomerular layer as well as several of their synaptic targets in the adult mouse olfactory bulb. Both peripheral and serotoninergic inputs controlled VGLUT3+ neurons firing. Furthermore, we show that VGLUT3+ neurons photostimulation in vivo strongly suppresses both spontaneous and odor–evoked firing of bulbar output neurons. In conclusion, we characterized a novel microcircuit controlling the transfer of sensory information at an early stage of the olfactory pathway.

eng
Keywords
  • Vesicular glutamate transporter
  • Olfaction
  • External tufted cells
  • Serotonin
  • Channelrhodopsin
NoteDiplôme commun des univ. de Genève et Lausanne. Doctorat en Neurosciences des Universités de Genève et de Lausanne
Citation (ISO format)
TATTI, Roberta. Vesicular glutamate transporter 3 expressing neurons gate output pathways of the mouse olfactory bulb. 2013. doi: 10.13097/archive-ouverte/unige:31519
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Creation11/21/2013 11:45:00 AM
First validation11/21/2013 11:45:00 AM
Update time03/14/2023 8:39:19 PM
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