Scientific article
Open access

The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats

Published inBrain and behavior, vol. 2, no. 4, p. 402-414
Publication date2012

JAM-C is a junctional adhesion molecule, enriched at tight junctions on endothelial and epithelial cells, and also localized to Schwann cells at junctions between adjoining myelin end loops. The role of JAM-C following peripheral nerve injury (PNI) is currently unknown. We examined the localization of JAM-C after sciatic nerve crush injury in adult rats. JAM-C immunoreactivity was present in paranodes and incisures in sham surgery control nerve, but distal to the crush injury significantly decreased at three and 14 days. JAM-C was re-expressed at 28 days and, by 56 days, was significantly increased in the distal nerve compared to controls. In a 7-mm length of sciatic nerve sampled distal to the crush site, the densities of JAM-C immunoreactive paranodes increased in the distal direction. Conversely, the densities of JAM-C immunoreactive incisures were highest immediately distal to the crush site and decreased in the more distal direction. Further analysis revealed a strong correlation between JAM-C localization and remyelination. Fifty-six days after crush injury, greater densities of JAM-C paranodes were seen compared to the nodal marker jacalin, suggesting that paranodal JAM-C precedes node formation. Our data are the first to demonstrate a potential role of JAM-C in remyelination after PNI.

Citation (ISO format)
AVARI, Parizad et al. The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats. In: Brain and behavior, 2012, vol. 2, n° 4, p. 402–414. doi: 10.1002/brb3.63
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Article (Published version)
ISSN of the journal2162-3279

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