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The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats

Contributors

Avari, Parizad; Huang, Wenlong; Averill, Sharon; Colom, Bartomeu; Imhof, Beat; Nourshargh, Sussan; Priestley, John V

Published in

Brain and behavior, vol. 2, no. 4, p. 402-414

Publication date

2012

Abstract

JAM-C is a junctional adhesion molecule, enriched at tight junctions on endothelial and epithelial cells, and also localized to Schwann cells at junctions between adjoining myelin end loops. The role of JAM-C following peripheral nerve injury (PNI) is currently unknown. We examined the localization of JAM-C after sciatic nerve crush injury in adult rats. JAM-C immunoreactivity was present in paranodes and incisures in sham surgery control nerve, but distal to the crush injury significantly decreased at three and 14 days. JAM-C was re-expressed at 28 days and, by 56 days, was significantly increased in the distal nerve compared to controls. In a 7-mm length of sciatic nerve sampled distal to the crush site, the densities of JAM-C immunoreactive paranodes increased in the distal direction. Conversely, the densities of JAM-C immunoreactive incisures were highest immediately distal to the crush site and decreased in the more distal direction. Further analysis revealed a strong correlation between JAM-C localization and remyelination. Fifty-six days after crush injury, greater densities of JAM-C paranodes were seen compared to the nodal marker jacalin, suggesting that paranodal JAM-C precedes node formation. Our data are the first to demonstrate a potential role of JAM-C in remyelination after PNI.

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

AVARI, Parizad et al. The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats. In: Brain and behavior, 2012, vol. 2, n° 4, p. 402–414. doi: 10.1002/brb3.63

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Article (Published version)

Identifiers

Journal ISSN

2162-3279
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Technical informations

Creation

27/11/2013 11:23:00

First validation

27/11/2013 11:23:00

Update

14/03/2023 20:38:51

Status update

14/03/2023 20:38:51

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