UNIGE document Scientific Article
previous document  unige:31440  next document
add to browser collection

The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats

Avari, Parizad
Huang, Wenlong
Averill, Sharon
Colom, Bartomeu
Nourshargh, Sussan
Priestley, John V
Published in Brain and behavior. 2012, vol. 2, no. 4, p. 402-14
Abstract JAM-C is a junctional adhesion molecule, enriched at tight junctions on endothelial and epithelial cells, and also localized to Schwann cells at junctions between adjoining myelin end loops. The role of JAM-C following peripheral nerve injury (PNI) is currently unknown. We examined the localization of JAM-C after sciatic nerve crush injury in adult rats. JAM-C immunoreactivity was present in paranodes and incisures in sham surgery control nerve, but distal to the crush injury significantly decreased at three and 14 days. JAM-C was re-expressed at 28 days and, by 56 days, was significantly increased in the distal nerve compared to controls. In a 7-mm length of sciatic nerve sampled distal to the crush site, the densities of JAM-C immunoreactive paranodes increased in the distal direction. Conversely, the densities of JAM-C immunoreactive incisures were highest immediately distal to the crush site and decreased in the more distal direction. Further analysis revealed a strong correlation between JAM-C localization and remyelination. Fifty-six days after crush injury, greater densities of JAM-C paranodes were seen compared to the nodal marker jacalin, suggesting that paranodal JAM-C precedes node formation. Our data are the first to demonstrate a potential role of JAM-C in remyelination after PNI.
PMID: 22950044
Full text
Article (Published version) (567 Kb) - public document Free access
Research group Molécules d'adhésion et processus de migration cellulaire (167)
(ISO format)
AVARI, Parizad et al. The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats. In: Brain and behavior, 2012, vol. 2, n° 4, p. 402-14. doi: 10.1002/brb3.63 https://archive-ouverte.unige.ch/unige:31440

487 hits



Deposited on : 2013-11-27

Export document
Format :
Citation style :