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Acute norovirus-induced agranulocytosis in a pediatric kidney transplant recipient

Chehade, H
Delich, V
Pascual, M-A
Venetz, J-P
Cachat, F
Published in Transplant infectious disease. 2012, vol. 14, no. 4, p. E27-9
Abstract Norovirus (NoV) infection is usually limited to the gastrointestinal (GI) tract. However, in immunocompromised patients, this infection might lead to severe life-threatening complications. We herein describe a pediatric kidney transplant patient who presented with an acute NoV infection complicated by febrile agranulocytosis that resolved with improvement of her GI illness. This unusual presentation has not been described before, to our knowledge. The aim of this article is to highlight the sometimes dramatic clinical presentation of NoV infection in immunosuppressed patients, and the importance of including this infection in the differential diagnosis of neutropenia in that specific population.
Keywords Acute DiseaseAgranulocytosis/virologyCaliciviridae Infections/complications/virologyChildFemaleHumansImmunocompromised HostKidney Transplantation/adverse effectsNorovirus/pathogenicity
PMID: 22676808
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Research group Pathogénèse du syndrome néphrotique idiopathique de l'enfant (180)
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CHEHADE, H et al. Acute norovirus-induced agranulocytosis in a pediatric kidney transplant recipient. In: Transplant infectious disease, 2012, vol. 14, n° 4, p. E27-9. doi: 10.1111/j.1399-3062.2012.00754.x https://archive-ouverte.unige.ch/unige:31423

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Deposited on : 2013-11-27

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