Differential effects of sodium oxybate and baclofen on EEG, sleep, neurobehavioral performance, and memory

Vienne, Julie; Lecciso, Gianpaolo; Constantinescu, Irina Oana; Schwartz, Sophie; Franken, Paul; Heinzer, Raphael; Tafti, Mehdi

doi:10.5665/sleep.1992

Scientific article

Open access

English

Differential effects of sodium oxybate and baclofen on EEG, sleep, neurobehavioral performance, and memory

ContributorsVienne, Julie; Lecciso, Gianpaolo; Constantinescu, Irina Oana; Schwartz, Sophie

; Franken, Paul; Heinzer, Raphael; Tafti, Mehdi

Published inSleep, vol. 35, no. 8, p. 1071-1083

Publication date2012

Abstract

Sodium oxybate (SO) is a GABAβ agonist used to treat the sleep disorder narcolepsy. SO was shown to increase slow wave sleep (SWS) and EEG delta power (0.75-4.5 Hz), both indexes of NREM sleep (NREMS) intensity and depth, suggesting that SO enhances recuperative function of NREM. We investigated whether SO induces physiological deep sleep.

Affiliation

Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

Research group

Neuroimagerie du Sommeil et de la Cognition (832)

Citation (ISO format)

VIENNE, Julie et al. Differential effects of sodium oxybate and baclofen on EEG, sleep, neurobehavioral performance, and memory. In: Sleep, 2012, vol. 35, n° 8, p. 1071–1083. doi: 10.5665/sleep.1992

Article (Published version)

Identifiers

PID : unige:31375
DOI : 10.5665/sleep.1992
PMID : 22851803

ISSN of the journal0161-8105

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Differential effects of sodium oxybate and baclofen on EEG, sleep, neurobehavioral performance, and memory

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