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Suivi du patient après transplantation cardiaque : monitoring et adaptation de l’immunosuppression

Vogt, P
Hullin, R
Pascual, M
Published in Revue médicale suisse. 2009, vol. 5, no. 205, p. 1214-6,1218-20
Abstract Heart transplantation remains the best therapeutic option for the treatment of end-stage heart failure. However, good survival rates can be obtained only if patients are closely monitored, particularly for their immunosuppressive regimens. Currently, a triple-drug regimen usually based on calcineurin-inhibitors (cyclosporin A or tacrolimus), anti-proliferative agents and steroids is used in most recipients. New agents such as the mTOR inhibitors, a more recently developed class of immunosuppressive drugs, can also be used in some patients. The aim of this article is to review currently used immunosuppressive regimens after heart transplantation, and to propose some individualized options depending on specific patient characteristics and recent pharmacological developments in the field.
Keywords Chronic DiseaseClinical Trials as TopicCyclosporine/administration & dosageDrug Therapy, CombinationGlucocorticoids/administration & dosageGraft Rejection/prevention & controlGraft Survival/drug effectsHeart Failure/surgeryHeart TransplantationHumansImmunosuppression/methodsImmunosuppressive Agents/administration & dosageMeta-Analysis as TopicMonitoring, Immunologic/methodsMycophenolic Acid/administration & dosage/analogs & derivativesProtein Kinases/drug effectsRandomized Controlled Trials as TopicSirolimus/administration & dosageSurvival AnalysisT-Lymphocytes/drug effectsTOR Serine-Threonine KinasesTacrolimus/administration & dosageTreatment Outcome
PMID: 19517754
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Other version: http://rms.medhyg.ch/numero-205-page-1214.htm
Research groups Chirurgie cardio-vasculaire (105)
Biologie du myocarde (22)
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YERLY, Patrick Oliver et al. Suivi du patient après transplantation cardiaque : monitoring et adaptation de l’immunosuppression. In: Revue médicale suisse, 2009, vol. 5, n° 205, p. 1214-6,1218-20. https://archive-ouverte.unige.ch/unige:31263

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Deposited on : 2013-11-22

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