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Secondary pulmonary alveolar proteinosis after unrelated cord blood hematopoietic cell transplantation

Le Deist, Françoise
Duval, Michel
Champagne, Martin A
Fournet, Jean-Christophe
Published in Pediatric Transplantation. 2012, vol. 16, no. 5, p. E146-9
Abstract PAP is a rare alveolointerstitial lung disorder characterized histologically by the intra-alveolar accumulation of eosinophilic and PAS-positive material. We observed two cases of PAP after unrelated CB hematopoietic progenitor cell transplantation in children with ALL. No antagonist activity toward GM-CSF was identified in the patient tested. The putative multifactorial PAP etiology is discussed. This potentially curable condition should be considered in a CB allograft recipient with alveolointerstial lung disorder.
Keywords AdolescentChild, PreschoolCord Blood Stem Cell TransplantationFatal OutcomeFemaleHematopoietic Stem Cell TransplantationHumansMalePostoperative Complications/diagnosis/etiologyPrecursor Cell Lymphoblastic Leukemia-Lymphoma/surgeryPulmonary Alveolar Proteinosis/diagnosis/etiology
PMID: 21395954
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Research groups Groupe Ozsahin Ayse Hulya (onco-hémato pédiatrie) (889)
Plateforme d'oncologie et d'hématologie pédiatrique (907)
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ANSARI DJABERI, Marc Georges et al. Secondary pulmonary alveolar proteinosis after unrelated cord blood hematopoietic cell transplantation. In: Pediatric Transplantation, 2012, vol. 16, n° 5, p. E146-9. https://archive-ouverte.unige.ch/unige:31212

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Deposited on : 2013-11-20

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