en
Scientific article
Case report
English

Secondary pulmonary alveolar proteinosis after unrelated cord blood hematopoietic cell transplantation

Published inPediatric transplantation, vol. 16, no. 5, p. E146-149
Publication date2012
Abstract

PAP is a rare alveolointerstitial lung disorder characterized histologically by the intra-alveolar accumulation of eosinophilic and PAS-positive material. We observed two cases of PAP after unrelated CB hematopoietic progenitor cell transplantation in children with ALL. No antagonist activity toward GM-CSF was identified in the patient tested. The putative multifactorial PAP etiology is discussed. This potentially curable condition should be considered in a CB allograft recipient with alveolointerstial lung disorder.

Keywords
  • Adolescent
  • Child, Preschool
  • Cord Blood Stem Cell Transplantation
  • Fatal Outcome
  • Female
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Male
  • Postoperative Complications/diagnosis/etiology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma/surgery
  • Pulmonary Alveolar Proteinosis/diagnosis/etiology
Citation (ISO format)
ANSARI DJABERI, Marc Georges et al. Secondary pulmonary alveolar proteinosis after unrelated cord blood hematopoietic cell transplantation. In: Pediatric transplantation, 2012, vol. 16, n° 5, p. E146–149. doi: 10.1111/j.1399-3046.2011.01487.x
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Article (Published version)
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Identifiers
ISSN of the journal1397-3142
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