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Antibody response in MOG35–55 induced EAE

Published inJournal of neuroimmunology, vol. 240-241, p. 28-33
Publication date2011
Abstract

Neurological deficit in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis is widely considered to be a consequence of synergistic T and B cell responses to central nervous system (CNS) antigens. We show that mice immunized with encephalitogenic myelin oligodendrocyte glycoprotein (MOG35–55) peptide develop significant serum levels of anti-MOG antibodies in parallel with disease progression. Furthermore, EAE mice developed antibodies against DNA and RNA, a serological hallmark observed in autoimmune diseases such as systemic lupus erythematosus. The presence of anti-nucleic responsive B cells and antibodies during EAE may highlight a previously unappreciated mechanism in the pathogenesis of CNS autoimmunity.

Citation (ISO format)
LALIVE D’EPINAY, Patrice et al. Antibody response in MOG35–55 induced EAE. In: Journal of neuroimmunology, 2011, vol. 240-241, p. 28–33. doi: 10.1016/j.jneuroim.2011.09.005
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ISSN of the journal0165-5728
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