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Antibody response in MOG35–55 induced EAE

Weber, Martin S.
Published in Journal of Neuroimmunology. 2011, vol. 240-241, p. 28-33
Abstract Neurological deficit in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis is widely considered to be a consequence of synergistic T and B cell responses to central nervous system (CNS) antigens. We show that mice immunized with encephalitogenic myelin oligodendrocyte glycoprotein (MOG35–55) peptide develop significant serum levels of anti-MOG antibodies in parallel with disease progression. Furthermore, EAE mice developed antibodies against DNA and RNA, a serological hallmark observed in autoimmune diseases such as systemic lupus erythematosus. The presence of anti-nucleic responsive B cells and antibodies during EAE may highlight a previously unappreciated mechanism in the pathogenesis of CNS autoimmunity.
PMID: 21993076
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Research groups Groupe Santiago-Raber Marie-Laure (pathologie et immunologie) (915)
Scléroses en plaques, neuroimmunologie, encéphalite autoimmune expérimentale (843)
Projects FNS: 310030-132705
Swiss Multiple Sclerosis Society
(ISO format)
LALIVE D'EPINAY, Patrice et al. Antibody response in MOG35–55 induced EAE. In: Journal of Neuroimmunology, 2011, vol. 240-241, p. 28-33. https://archive-ouverte.unige.ch/unige:31004

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Deposited on : 2013-11-12

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