en
Scientific article
Review
English

Anchors aweigh: protein localization and transport mediated by transmembrane domains

Published inTrends in cell biology, vol. 23, no. 10, p. 511-517
Publication date2013
Abstract

The transmembrane domains (TMDs) of integral membrane proteins have emerged as major determinants of intracellular localization and transport in the secretory and endocytic pathways. Unlike sorting signals in cytosolic domains, TMD sorting determinants are not conserved amino acid sequences but physical properties such as the length and hydrophilicity of the transmembrane span. The underlying sorting machinery is still poorly characterized, but several mechanisms have been proposed, including TMD recognition by transmembrane sorting receptors and partitioning into membrane lipid domains. Here we review the nature of TMD sorting determinants and how they may dictate transmembrane protein localization and transport.

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Citation (ISO format)
COSSON, Pierre, PERRIN SIMONNOT, Jackie, BONIFACINO, Juan S. Anchors aweigh: protein localization and transport mediated by transmembrane domains. In: Trends in cell biology, 2013, vol. 23, n° 10, p. 511–517. doi: 10.1016/j.tcb.2013.05.005
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ISSN of the journal0962-8924
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Creation10/07/2013 8:59:00 PM
First validation10/07/2013 8:59:00 PM
Update time03/14/2023 8:35:28 PM
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