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Title

Radiation-induced craniofacial bone growth inhibition: acute and long-term effects on bone histopathology with and without cytoprotection

Authors
OʼDonovan, David A
Leong, Iona
Mendes, Maria
Rogers, Marianne
Pritzker, Kenneth H
Yeung, Ivan
Pang, Cho Y
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Published in Plastic and Reconstructive Surgery. 2012, vol. 129, no. 4, p. 636e-45e
Abstract The authors previously established an animal model of radiation-induced craniofacial bone growth inhibition and demonstrated the effectiveness of cytoprotection in preserving growth using amifostine, but the mechanism is unclear. The objective of this study was to investigate the acute and long-term histopathologic effects of single-dose orthovoltage irradiation on craniofacial bone with and without cytoprotection.
Keywords Amifostine/pharmacologyAnimalsBone RemodelingCell Proliferation/drug effects/radiation effectsDose-Response Relationship, RadiationKi-67 Antigen/analysisMaleOrbit/drug effects/growth & development/pathology/radiation effectsOsteoblasts/drug effects/pathology/radiation effectsPeriosteum/metabolism/pathologyRabbitsRadiation DosageRadiation-Protective Agents/pharmacologyZygoma/drug effects/growth & development/pathology/radiation effects
Identifiers
PMID: 22456377
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Research group Recherche clinique en chirurgie pédiatrique (886)
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OʼDONOVAN, David A et al. Radiation-induced craniofacial bone growth inhibition: acute and long-term effects on bone histopathology with and without cytoprotection. In: Plastic and Reconstructive Surgery, 2012, vol. 129, n° 4, p. 636e-45e. https://archive-ouverte.unige.ch/unige:30610

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Deposited on : 2013-10-23

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