Radiation-induced craniofacial bone growth inhibition: acute and long-term effects on bone histopathology with and without cytoprotection

OʼDonovan, David A; La Scala, Giorgio; Leong, Iona; Mendes, Maria; Rogers, Marianne; Pritzker, Kenneth H; Yeung, Ivan; Pang, Cho Y; Neligan, Peter C; Forrest, Christopher R

doi:10.1097/PRS.0b013e31824421b6

Scientific article

English

Radiation-induced craniofacial bone growth inhibition: acute and long-term effects on bone histopathology with and without cytoprotection

ContributorsOʼDonovan, David A; La Scala, Giorgio; Leong, Iona; Mendes, Maria; Rogers, Marianne; Pritzker, Kenneth H; Yeung, Ivan; Pang, Cho Y; Neligan, Peter C; Forrest, Christopher R

Published inPlastic and reconstructive surgery, vol. 129, no. 4, p. 636e-45e

Publication date2012

Abstract

The authors previously established an animal model of radiation-induced craniofacial bone growth inhibition and demonstrated the effectiveness of cytoprotection in preserving growth using amifostine, but the mechanism is unclear. The objective of this study was to investigate the acute and long-term histopathologic effects of single-dose orthovoltage irradiation on craniofacial bone with and without cytoprotection.

Keywords

Amifostine/pharmacology
Animals
Bone Remodeling
Cell Proliferation/drug effects/radiation effects
Dose-Response Relationship, Radiation
Ki-67 Antigen/analysis
Male
Orbit/drug effects/growth & development/pathology/radiation effects
Osteoblasts/drug effects/pathology/radiation effects
Periosteum/metabolism/pathology
Rabbits
Radiation Dosage
Radiation-Protective Agents/pharmacology
Zygoma/drug effects/growth & development/pathology/radiation effects

Affiliation

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research group

Recherche clinique en chirurgie pédiatrique (886)

Citation (ISO format)

OʼDONOVAN, David A et al. Radiation-induced craniofacial bone growth inhibition: acute and long-term effects on bone histopathology with and without cytoprotection. In: Plastic and reconstructive surgery, 2012, vol. 129, n° 4, p. 636e–45e. doi: 10.1097/PRS.0b013e31824421b6

Article (Published version)

Identifiers

PID : unige:30610
DOI : 10.1097/PRS.0b013e31824421b6
PMID : 22456377

ISSN of the journal0032-1052

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Radiation-induced craniofacial bone growth inhibition: acute and long-term effects on bone histopathology with and without cytoprotection

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