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Title

Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis

Authors
Ruperto, Nicolino
Brunner, Hermine I
Quartier, Pierre
Constantin, Tamás
Wulffraat, Nico
Horneff, Gerd
Brik, Riva
McCann, Liza
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Published in New England Journal of Medicine. 2012, vol. 367, no. 25, p. 2396-406
Abstract Interleukin-1 is pivotal in the pathogenesis of systemic juvenile idiopathic arthritis (JIA). We assessed the efficacy and safety of canakinumab, a selective, fully human, anti-interleukin-1β monoclonal antibody, in two trials.
Keywords AdolescentAnti-Inflammatory Agents, Non-Steroidal/therapeutic useAntibodies, Monoclonal/adverse effects/therapeutic useArthritis, Juvenile Rheumatoid/complications/drug therapyChildChild, PreschoolDouble-Blind MethodDrug Therapy, CombinationFemaleGlucocorticoids/therapeutic useHumansInfection/chemically inducedInterleukin-1beta/antagonists & inhibitorsKaplan-Meier EstimateMacrophage Activation Syndrome/etiologyMaleMethotrexate/therapeutic useNeutropenia/chemically inducedThrombocytopenia/chemically induced
Identifiers
PMID: 23252526
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Structures
Research group Pathogénèse du syndrome néphrotique idiopathique de l'enfant (180)
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RUPERTO, Nicolino et al. Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis. In: New England Journal of Medicine, 2012, vol. 367, n° 25, p. 2396-406. https://archive-ouverte.unige.ch/unige:30597

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Deposited on : 2013-10-23

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