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Title

Construction of Enantioenriched Cyclic Compounds by Asymmetric Allylic Alkylation and Ring-Closing Metathesis
Authors
Giacomina, Francesca
Alexakis, Alexandre
Published in European Journal of Organic Chemistry. 2013, vol. 2013, no. 29, p. 6710-6721
Abstract A new approach to highly enantioenriched cyclic compounds (up to 98 % ee) has been developed by using ω-ethylenic allylic substrates in a one-pot asymmetric allylic alkylation and ring-closing metathesis sequence. The starting compounds are synthetic equivalents of cyclic allylic substrates. The method is exemplified with both Cu and Ir catalysts, and chiral phosphoramidite ligands.
Keywords Asymmetric synthesis — Allylic alkylation — Cyclization — Metathesis — Copper — Iridium
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Article (Published version) (895 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Faculté des sciences / Section de chimie et biochimie / Département de chimie organique
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(ISO format) 		GIACOMINA, Francesca, ALEXAKIS, Alexandre. Construction of Enantioenriched Cyclic Compounds by Asymmetric Allylic Alkylation and Ring-Closing Metathesis. In: European Journal of Organic Chemistry, 2013, vol. 2013, n° 29, p. 6710-6721. doi: 10.1002/ejoc.201300971 https://archive-ouverte.unige.ch/unige:30348

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Deposited on : 2013-10-11

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