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Scientific article
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Construction of Enantioenriched Cyclic Compounds by Asymmetric Allylic Alkylation and Ring-Closing Metathesis

Published inEuropean journal of organic chemistry, vol. 2013, no. 29, p. 6710-6721
Publication date2013
Abstract

A new approach to highly enantioenriched cyclic compounds (up to 98 % ee) has been developed by using ω-ethylenic allylic substrates in a one-pot asymmetric allylic alkylation and ring-closing metathesis sequence. The starting compounds are synthetic equivalents of cyclic allylic substrates. The method is exemplified with both Cu and Ir catalysts, and chiral phosphoramidite ligands.

Keywords
  • Asymmetric synthesis
  • Allylic alkylation
  • Cyclization
  • Metathesis
  • Copper
  • Iridium
Citation (ISO format)
GIACOMINA, Francesca, ALEXAKIS, Alexandre. Construction of Enantioenriched Cyclic Compounds by Asymmetric Allylic Alkylation and Ring-Closing Metathesis. In: European journal of organic chemistry, 2013, vol. 2013, n° 29, p. 6710–6721. doi: 10.1002/ejoc.201300971
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ISSN of the journal1099-0690
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Creation10/10/2013 10:15:00 AM
First validation10/10/2013 10:15:00 AM
Update time03/14/2023 8:32:31 PM
Status update03/14/2023 8:32:31 PM
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