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Construction of Enantioenriched Cyclic Compounds by Asymmetric Allylic Alkylation and Ring-Closing Metathesis

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Published in European Journal of Organic Chemistry. 2013, vol. 2013, no. 29, p. 6710-6721
Abstract A new approach to highly enantioenriched cyclic compounds (up to 98 % ee) has been developed by using ω-ethylenic allylic substrates in a one-pot asymmetric allylic alkylation and ring-closing metathesis sequence. The starting compounds are synthetic equivalents of cyclic allylic substrates. The method is exemplified with both Cu and Ir catalysts, and chiral phosphoramidite ligands.
Keywords Asymmetric synthesisAllylic alkylationCyclizationMetathesisCopperIridium
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Other version: http://doi.wiley.com/10.1002/ejoc.201300971
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GIACOMINA, Francesca, ALEXAKIS, Alexandre. Construction of Enantioenriched Cyclic Compounds by Asymmetric Allylic Alkylation and Ring-Closing Metathesis. In: European Journal of Organic Chemistry, 2013, vol. 2013, n° 29, p. 6710-6721. https://archive-ouverte.unige.ch/unige:30348

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Deposited on : 2013-10-11

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