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De Novo Production of Metabolites by Fungal Co-culture of Trichophyton rubrum and Bionectria ochroleuca

Monod, Michel
Gindro, Katia
Published in Journal of Natural Products. 2013, vol. 76, no. 6, p. 1157-1165
Abstract The co-cultivation of fungi has recently been described as a promising strategy to induce the production of novel metabolites through possible gene activation. A large screening of fungal co-cultures in solid media has identified an unusual long-distance growth inhibition between Trichophyton rubrum and Bionectria ochroleuca. To study metabolite induction in this particular fungal interaction, differential LC-MS-based metabolomics was performed on pure strain cultures and on their co-cultures. The comparison of the resulting fingerprints highlighted five de novo induced compounds, which were purified using software-oriented semipreparative HPLC-MS. One metabolite was successfully identified as 4″-hydroxysulfoxy-2,2″-dimethylthielavin P (a substituted trimer of 3,5-dimethylorsellinic acid). The nonsulfated form, as well as three other related compounds, were found in the pure strain culture of B. ochroleuca.
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Other version: http://pubs.acs.org/doi/abs/10.1021/np400258f
Research group Phytochimie et produits naturels bioactifs
Project FNS: CRSII3_127187
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BERTRAND, Samuel et al. De Novo Production of Metabolites by Fungal Co-culture of Trichophyton rubrum and Bionectria ochroleuca. In: Journal of Natural Products, 2013, vol. 76, n° 6, p. 1157-1165. https://archive-ouverte.unige.ch/unige:30312

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Deposited on : 2013-10-09

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