UNIGE document Doctoral Thesis
previous document  unige:30280  next document
add to browser collection
Title

Role of the glycoproteins in the production of Sendai virus particles

Author
Directors
Defense Thèse de doctorat : Univ. Genève, 2013 - Sc. 4582 - 2013/07/11
Abstract Previous studies have shown the importance of the Glycoproteins during Sendai virus particle (VP) production. My PhD thesis aims at describing in details the involvement of the F and HN proteins in the process of SeV particle formation. This study performed exclusively in the context of rSeV infections includes: -Identification of the mechanism of action of the F cytoplasmic tail motif, TYTLE, during assembly and budding and its potential interaction with virus proteins and/or cellular machinery. -Determination of HN domains and residues, including the SYWST motif, needed for its uptake into virion. -Global understanding of the molecular mechanism of assembly and budding via the consolidation of outcomes from the two first studies and some additional data. In the end, this thesis work will allow proposing a model for dynamic SeV assembly leading to precursor complex formation and finally virus egress during the last steps of the infection.
Keywords Sendai virusVirus particle formationParamyxovirusGlycoprotein
Identifiers
URN: urn:nbn:ch:unige-302802
Full text
Thesis (7.2 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Citation
(ISO format)
ESSAIDI, Manel. Role of the glycoproteins in the production of Sendai virus particles. Université de Genève. Thèse, 2013. https://archive-ouverte.unige.ch/unige:30280

264 hits

11 downloads

Update

Deposited on : 2013-10-07

Export document
Format :
Citation style :