en
Scientific article
Open access
English

Co-evolutionary dynamics of the bacteria Vibrio sp. CV1 and Phages V1G, V1P1, and V1P2: implications for Phage therapy

Published inMicrobial ecology, vol. 66, no. 4, p. 897-905
Collection
  • Open Access - Licence nationale Springer
Publication date2013
Abstract

Bacterial infections are the second largest cause of mortality in shrimp hatcheries. Among them, bacteria from the genus Vibrio constitute a major threat. As the use of antibiotics may be ineffective and banned from the food sector, alternatives are required. Historically, phage therapy, which is the use of bacteriophages, is thought to be a promising option to fight against bacterial infections. However, as for antibiotics, resistance can be rapidly developed. Since the emergence of resistance is highly undesirable, a formal characterization of the dynamics of its acquisition is mandatory. Here, we explored the co-evolutionary dynamics of resistance between the bacteria Vibrio sp. CV1 and the phages V1G, V1P1, and V1P2. Singlephage treatments as well as a cocktail composed of the three phages were considered. We found that in the presence of a single phage, bacteria rapidly evolved resistance, and the phages decreased their infectivity, suggesting thatmonotherapy may be an inefficient treatment to fight against Vibrio infections in shrimp hatcheries. On the contrary, the use of a phage cocktail considerably delayed the evolution of resistance and sustained phage infectivity for periods in which shrimp larvae are most susceptible to bacterial infections, suggesting the simultaneous use of multiple phages as a serious strategy for the control of vibriosis. These findings are very promising in terms of their consequences to different industrial and medical scenarios where bacterial infections are present.

Citation (ISO format)
BARBOSA, Camilo et al. Co-evolutionary dynamics of the bacteria Vibrio sp. CV1 and Phages V1G, V1P1, and V1P2: implications for Phage therapy. In: Microbial ecology, 2013, vol. 66, n° 4, p. 897–905. doi: 10.1007/s00248-013-0284-2
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0095-3628
642views
338downloads

Technical informations

Creation09/26/2013 8:26:00 AM
First validation09/26/2013 8:26:00 AM
Update time03/14/2023 8:31:56 PM
Status update03/14/2023 8:31:55 PM
Last indexation01/16/2024 7:49:52 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack