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Scientific article
Open access
English

The Ccr4-Not complex interacts with the mRNA export machinery

Published inPloS one, vol. 6, no. 3, e18302
Publication date2011
Abstract

The Ccr4-Not complex is a key eukaryotic regulator of gene transcription and cytoplasmic mRNA degradation. Whether this complex also affects aspects of post-transcriptional gene regulation, such as mRNA export, remains largely unexplored. Human Caf1 (hCaf1), a Ccr4-Not complex member, interacts with and regulates the arginine methyltransferase PRMT1, whose targets include RNA binding proteins involved in mRNA export. However, the functional significance of this regulation is poorly understood.

Keywords
  • Heterogeneous-Nuclear Ribonucleoproteins/metabolism
  • Humans
  • Multiprotein Complexes/metabolism
  • Mutant Proteins/metabolism
  • Mutation/genetics
  • Nuclear Pore/metabolism
  • Poly A/metabolism
  • Protein Binding
  • Protein Subunits/metabolism
  • Protein-Arginine N-Methyltransferases/metabolism
  • RNA Processing, Post-Transcriptional
  • RNA Transport
  • RNA, Messenger/genetics/metabolism
  • Repressor Proteins/metabolism
  • Ribonucleases/isolation & purification/metabolism
  • Saccharomyces cerevisiae/cytology/growth & development/metabolism
  • Saccharomyces cerevisiae Proteins/isolation & purification/metabolism
Citation (ISO format)
KERR, Shana C et al. The Ccr4-Not complex interacts with the mRNA export machinery. In: PloS one, 2011, vol. 6, n° 3, p. e18302. doi: 10.1371/journal.pone.0018302
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal1932-6203
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