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Title

The Ccr4-Not complex interacts with the mRNA export machinery

Authors
Kerr, Shana C
Fuchs, Stephen M
Strahl, Brian D
Corbett, Anita H
Laribee, R Nicholas
Published in PLOS ONE. 2011, vol. 6, no. 3, p. e18302
Abstract The Ccr4-Not complex is a key eukaryotic regulator of gene transcription and cytoplasmic mRNA degradation. Whether this complex also affects aspects of post-transcriptional gene regulation, such as mRNA export, remains largely unexplored. Human Caf1 (hCaf1), a Ccr4-Not complex member, interacts with and regulates the arginine methyltransferase PRMT1, whose targets include RNA binding proteins involved in mRNA export. However, the functional significance of this regulation is poorly understood.
Keywords Heterogeneous-Nuclear Ribonucleoproteins/metabolismHumansMultiprotein Complexes/metabolismMutant Proteins/metabolismMutation/geneticsNuclear Pore/metabolismPoly A/metabolismProtein BindingProtein Subunits/metabolismProtein-Arginine N-Methyltransferases/metabolismRNA Processing, Post-TranscriptionalRNA TransportRNA, Messenger/genetics/metabolismRepressor Proteins/metabolismRibonucleases/isolation & purification/metabolismSaccharomyces cerevisiae/cytology/growth & development/metabolismSaccharomyces cerevisiae Proteins/isolation & purification/metabolism
Identifiers
PMID: 21464899
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Article (Published version) (1.2 MB) - public document Free access
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Research group Groupe Collart Martine (microbiologie et médecine moléculaire) (81)
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KERR, Shana C et al. The Ccr4-Not complex interacts with the mRNA export machinery. In: PLOS ONE, 2011, vol. 6, n° 3, p. e18302. https://archive-ouverte.unige.ch/unige:30085

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Deposited on : 2013-10-01

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