Systematic review and meta-analysis of the effect of perioperative steroids on ischaemia-reperfusion injury and surgical stress response in patients undergoing liver resection

Orci, Lorenzo; Toso, Christian; Mentha, Gilles; Morel, Philippe; Majno, Pietro

doi:10.1002/bjs.9035

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Title		Systematic review and meta-analysis of the effect of perioperative steroids on ischaemia-reperfusion injury and surgical stress response in patients undergoing liver resection
Authors		Orci, Lorenzo Toso, Christian Mentha, Gilles Morel, Philippe Majno, Pietro
Published in		British journal of surgery. 2013, vol. 100, no. 5, p. 600-9
Abstract		Several therapeutic strategies, such as ischaemic preconditioning, intermittent or selective pedicle clamping and pharmacological interventions, have been explored to reduce morbidity caused by hepatic ischaemia-reperfusion injury and the surgical stress response. The role of steroids in this setting remains controversial.
Keywords		Adrenal Cortex Hormones/administration & dosage — Alanine Transaminase/metabolism — Aspartate Aminotransferases/metabolism — Bilirubin/metabolism — Constriction — Humans — Interleukin-6/metabolism — Liver/surgery — Liver Diseases/surgery — Operative Time — Perioperative Care/methods — Postoperative Complications/etiology — Reperfusion Injury/prevention & control — Steroids/administration & dosage
Identifiers		DOI: 10.1002/bjs.9035 PMID: 23339056
Full text		Article (Published version) (137 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de chirurgie
Research groups		Chirurgie viscérale (104) Chirurgie viscérale (HUG) Hépatologie chirurgicale (327) Transplantation et hépatologie (905)
Citation (ISO format)		ORCI, Lorenzo et al. Systematic review and meta-analysis of the effect of perioperative steroids on ischaemia-reperfusion injury and surgical stress response in patients undergoing liver resection. In: British journal of surgery, 2013, vol. 100, n° 5, p. 600-9. doi: 10.1002/bjs.9035 https://archive-ouverte.unige.ch/unige:29963