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Title

Practical Synthesis of SimplePhos Ligands: Further Development of Alkyl-Substituted Phosphanamines
Authors
Mueller, Daniel
Guenee, Laure
Alexakis, Alexandre
Published in European Journal of Organic Chemistry. 2013, vol. 2013, no. 28, p. 6335–6343
Abstract Herein we disclose a rapid and easy synthetic procedure to access aryl- and alkyl-substituted phosphanamines (SimplePhos ligands). During the synthesis of a library of diverse aryl-substituted phosphanamine ligands we also found that alkyl-substituted phosphanamines can be synthesized and handled easily. This was unexpected as a previous report described them as highly air-sensitive compounds. Subsequently, we created a library of alkyl-substituted phosphanamines and found some to be highly efficient ligands in copper-catalyzed reactions such as the Cu-catalyzed asymmetric conjugate addition and propargylic alkylation reactions. Moreover, our efforts towards the synthesis of SimplePhos ligands led to the development of an easy and practical synthesis of diaryl(chloro)phosphanes, which is also presented in this paper.
Keywords Synthetic methods — Ligand design — Phosphane ligands
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Article (Published version) (1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://doi.wiley.com/10.1002/ejoc.201300729
Structures
Faculté des sciences / Section de chimie et biochimie / Département de chimie organique
Citation
(ISO format) 		MUELLER, Daniel, GUENEE, Laure, ALEXAKIS, Alexandre. Practical Synthesis of SimplePhos Ligands: Further Development of Alkyl-Substituted Phosphanamines. In: European Journal of Organic Chemistry, 2013, vol. 2013, n° 28, p. 6335–6343. https://archive-ouverte.unige.ch/unige:29943

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Deposited on : 2013-09-25

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