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Titles listPractical Synthesis of SimplePhos Ligands: Further Development of Alkyl-Substituted Phosphanamines
Titles listPractical Synthesis of SimplePhos Ligands: Further Development of Alkyl-Substituted Phosphanamines
Scientific Article
unige:29943 
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Practical Synthesis of SimplePhos Ligands: Further Development of Alkyl-Substituted Phosphanamines |
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| Published in | European Journal of Organic Chemistry. 2013, vol. 2013, no. 28, p. 6335–6343 | |
| Abstract | Herein we disclose a rapid and easy synthetic procedure to access aryl- and alkyl-substituted phosphanamines (SimplePhos ligands). During the synthesis of a library of diverse aryl-substituted phosphanamine ligands we also found that alkyl-substituted phosphanamines can be synthesized and handled easily. This was unexpected as a previous report described them as highly air-sensitive compounds. Subsequently, we created a library of alkyl-substituted phosphanamines and found some to be highly efficient ligands in copper-catalyzed reactions such as the Cu-catalyzed asymmetric conjugate addition and propargylic alkylation reactions. Moreover, our efforts towards the synthesis of SimplePhos ligands led to the development of an easy and practical synthesis of diaryl(chloro)phosphanes, which is also presented in this paper. | |
| Keywords | Synthetic methods — Ligand design — Phosphane ligands | |
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| Citation (ISO format) | MUELLER, Daniel, GUENEE, Laure, ALEXAKIS, Alexandre. Practical Synthesis of SimplePhos Ligands: Further Development of Alkyl-Substituted Phosphanamines. In: European Journal of Organic Chemistry, 2013, vol. 2013, n° 28, p. 6335–6343. doi: 10.1002/ejoc.201300729 https://archive-ouverte.unige.ch/unige:29943 |
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