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Scientific article
French

Maladie d'Alzheimer: de la pathogénie aux perspectives cliniques

Published inRevue médicale suisse, vol. 8, no. 354, p. 1770-1772,1774
Publication date2012
Abstract

The aim of this article is a critical review of the main pathogenetic issues debated in Alzheimer disease, with a focus on the clinical perspectives that could derive from. The pertinence of the amyloid cascade hypothesis as a unique and causal explanation of cognitive deterioration is challenged in the light of recent therapeutic failures of clinical trials and increasing role of tau protein in clinical expression. The detection of very early and possibly preclinical stages of the disease emerges as a necessary condition for the efficacy of future amyloid or tau-oriented curative strategies. In this respect, the possibility of finding individual vulnerability markers--in the group of patients with "mild cognitive impairment" or even in cognitively intact subjects--represents a major challenge of the clinical research in this field.

Keywords
  • Alzheimer Disease/genetics/pathology
  • Alzheimer Vaccines
  • Amyloid beta-Peptides/immunology/metabolism
  • Amyloid beta-Protein Precursor/genetics
  • Humans
  • Plaque, Amyloid/pathology
  • Positron-Emission Tomography
Citation (ISO format)
COSTANZA, A et al. Maladie d’Alzheimer: de la pathogénie aux perspectives cliniques. In: Revue médicale suisse, 2012, vol. 8, n° 354, p. 1770–1772,1774.
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Identifiers
ISSN of the journal1660-9379
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