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Scientific article
English

Etiologies of Parkinsonism in a century-long autopsy-based cohort

Published inBrain pathology, vol. 23, no. 1, p. 28-33
Publication date2013
Abstract

We investigated the distribution of different etiologies underlying Parkinsonism in a hospital-based autopsy collection, studied the demographic data and evaluated diagnostic accuracy using histopathological examination as the gold standard. Out of a total of 9359 consecutive autopsy cases collected between 1914 and 2010, we identified 261 individuals who carried a clinical diagnosis of a Parkinsonian syndrome at death. A detailed neuropathological examination revealed idiopathic Parkinson's disease (PD) in 62.2%, progressive supranuclear palsy (PSP) in 4.2%, multiple system atrophy (MSA) in 2.3%, corticobasal degeneration (CBD) in 1.2%, postencephalitic Parkinsonism (PEP) in 2.7%, vascular Parkinsonism (VaP) in 8.8% and Alzheimer-type pathology (ATP) of the substantia nigra in 8%. The diagnostic accuracy of PD in our cohort was lower (71.2%) than those reported in previous studies, although it tended to increase during the last decades up to 85.7%. Of particular interest, we found that PD, while being the most frequent cause of Parkinsonism, was greatly overdiagnosed, with VaP and ATP being the most frequent confounding conditions.

Keywords
  • Adult
  • Aged
  • Aged, 80 and over
  • Autopsy
  • Brain/metabolism/pathology
  • Cohort Studies
  • Female
  • Hospitals/statistics & numerical data
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease/classification/epidemiology/etiology/pathology
Citation (ISO format)
HORVATH, Judit et al. Etiologies of Parkinsonism in a century-long autopsy-based cohort. In: Brain pathology, 2013, vol. 23, n° 1, p. 28–33. doi: 10.1111/j.1750-3639.2012.00611.x
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Article (Published version)
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ISSN of the journal1015-6305
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