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Etiologies of Parkinsonism in a century-long autopsy-based cohort

Published in Brain Pathology. 2013, vol. 23, no. 1, p. 28-33
Abstract We investigated the distribution of different etiologies underlying Parkinsonism in a hospital-based autopsy collection, studied the demographic data and evaluated diagnostic accuracy using histopathological examination as the gold standard. Out of a total of 9359 consecutive autopsy cases collected between 1914 and 2010, we identified 261 individuals who carried a clinical diagnosis of a Parkinsonian syndrome at death. A detailed neuropathological examination revealed idiopathic Parkinson's disease (PD) in 62.2%, progressive supranuclear palsy (PSP) in 4.2%, multiple system atrophy (MSA) in 2.3%, corticobasal degeneration (CBD) in 1.2%, postencephalitic Parkinsonism (PEP) in 2.7%, vascular Parkinsonism (VaP) in 8.8% and Alzheimer-type pathology (ATP) of the substantia nigra in 8%. The diagnostic accuracy of PD in our cohort was lower (71.2%) than those reported in previous studies, although it tended to increase during the last decades up to 85.7%. Of particular interest, we found that PD, while being the most frequent cause of Parkinsonism, was greatly overdiagnosed, with VaP and ATP being the most frequent confounding conditions.
Keywords AdultAgedAged, 80 and overAutopsyBrain/metabolism/pathologyCohort StudiesFemaleHospitals/statistics & numerical dataHumansMaleMiddle AgedParkinson Disease/classification/epidemiology/etiology/pathology
PMID: 22702335
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Research groups Groupe Bouras Constantin (neuropsychiatrie) (1)
Groupe Pierre Burkhard (neurologie) (154)
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HORVATH, Judit et al. Etiologies of Parkinsonism in a century-long autopsy-based cohort. In: Brain Pathology, 2013, vol. 23, n° 1, p. 28-33. doi: 10.1111/j.1750-3639.2012.00611.x https://archive-ouverte.unige.ch/unige:29905

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Deposited on : 2013-09-24

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