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Scientific Article
unige:29905 
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Etiologies of Parkinsonism in a century-long autopsy-based cohort |
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| Authors | ||
| Published in | Brain Pathology. 2013, vol. 23, no. 1, p. 28-33 | |
| Abstract | We investigated the distribution of different etiologies underlying Parkinsonism in a hospital-based autopsy collection, studied the demographic data and evaluated diagnostic accuracy using histopathological examination as the gold standard. Out of a total of 9359 consecutive autopsy cases collected between 1914 and 2010, we identified 261 individuals who carried a clinical diagnosis of a Parkinsonian syndrome at death. A detailed neuropathological examination revealed idiopathic Parkinson's disease (PD) in 62.2%, progressive supranuclear palsy (PSP) in 4.2%, multiple system atrophy (MSA) in 2.3%, corticobasal degeneration (CBD) in 1.2%, postencephalitic Parkinsonism (PEP) in 2.7%, vascular Parkinsonism (VaP) in 8.8% and Alzheimer-type pathology (ATP) of the substantia nigra in 8%. The diagnostic accuracy of PD in our cohort was lower (71.2%) than those reported in previous studies, although it tended to increase during the last decades up to 85.7%. Of particular interest, we found that PD, while being the most frequent cause of Parkinsonism, was greatly overdiagnosed, with VaP and ATP being the most frequent confounding conditions. | |
| Keywords | Adult — Aged — Aged, 80 and over — Autopsy — Brain/metabolism/pathology — Cohort Studies — Female — Hospitals/statistics & numerical data — Humans — Male — Middle Aged — Parkinson Disease/classification/epidemiology/etiology/pathology | |
| Identifiers | PMID: 22702335 | |
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| Structures | ||
| Research groups | Groupe Bouras Constantin (neuropsychiatrie) (1) Groupe Pierre Burkhard (neurologie) (154) | |
| Citation (ISO format) | HORVATH, Judit et al. Etiologies of Parkinsonism in a century-long autopsy-based cohort. In: Brain Pathology, 2013, vol. 23, n° 1, p. 28-33. https://archive-ouverte.unige.ch/unige:29905 |
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