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Title

Interfering with leukocyte rolling--a promising therapeutic approach in inflammatory skin disorders?

Authors
Schon, Michael P.
Published in Trends in Pharmacological Sciences. 2003, vol. 24, no. 2, p. 49-52
Abstract Many novel anti-inflammatory compounds have been derived from research tools designed to better understand the complex process of leukocyte extravasation at sites of inflammation. Given that selectin-mediated rolling is the crucial initial step of leukocyte localization to the skin, specific interference with this mechanism is a particularly attractive target to treat cutaneous inflammation. Recently, several exciting advances have been reported aimed at selective interference with specific target molecules crucially involved in leukocyte rolling.
Keywords AnimalsAnti-Inflammatory Agents, Non-Steroidal/administration & dosage/metabolismDrug Delivery Systems/*methodsHumansInflammation/*drug therapy/metabolismLeukocyte Rolling/*drug effects/physiologySkin Diseases/*drug therapy/metabolism
Identifiers
PMID: 12559762
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BOEHNCKE, Wolf-Henning, SCHON, Michael P. Interfering with leukocyte rolling--a promising therapeutic approach in inflammatory skin disorders?. In: Trends in Pharmacological Sciences, 2003, vol. 24, n° 2, p. 49-52. https://archive-ouverte.unige.ch/unige:29880

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Deposited on : 2013-09-20

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