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Interfering with leukocyte rolling--a promising therapeutic approach in inflammatory skin disorders?
|Published in||Trends in Pharmacological Sciences. 2003, vol. 24, no. 2, p. 49-52|
|Abstract||Many novel anti-inflammatory compounds have been derived from research tools designed to better understand the complex process of leukocyte extravasation at sites of inflammation. Given that selectin-mediated rolling is the crucial initial step of leukocyte localization to the skin, specific interference with this mechanism is a particularly attractive target to treat cutaneous inflammation. Recently, several exciting advances have been reported aimed at selective interference with specific target molecules crucially involved in leukocyte rolling.|
|Keywords||Animals — Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/metabolism — Drug Delivery Systems/*methods — Humans — Inflammation/*drug therapy/metabolism — Leukocyte Rolling/*drug effects/physiology — Skin Diseases/*drug therapy/metabolism|
|BOEHNCKE, Wolf-Henning, SCHON, Michael P. Interfering with leukocyte rolling--a promising therapeutic approach in inflammatory skin disorders?. In: Trends in Pharmacological Sciences, 2003, vol. 24, n° 2, p. 49-52. https://archive-ouverte.unige.ch/unige:29880|