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Scientific article
English

Interfering with leukocyte rolling--a promising therapeutic approach in inflammatory skin disorders?

Published inTrends in pharmacological sciences, vol. 24, no. 2, p. 49-52
Publication date2003
Abstract

Many novel anti-inflammatory compounds have been derived from research tools designed to better understand the complex process of leukocyte extravasation at sites of inflammation. Given that selectin-mediated rolling is the crucial initial step of leukocyte localization to the skin, specific interference with this mechanism is a particularly attractive target to treat cutaneous inflammation. Recently, several exciting advances have been reported aimed at selective interference with specific target molecules crucially involved in leukocyte rolling.

Keywords
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/metabolism
  • Drug Delivery Systems/*methods
  • Humans
  • Inflammation/*drug therapy/metabolism
  • Leukocyte Rolling/*drug effects/physiology
  • Skin Diseases/*drug therapy/metabolism
Affiliation Not a UNIGE publication
Citation (ISO format)
BOEHNCKE, Wolf-Henning, SCHON, Michael P. Interfering with leukocyte rolling--a promising therapeutic approach in inflammatory skin disorders? In: Trends in pharmacological sciences, 2003, vol. 24, n° 2, p. 49–52. doi: 10.1016/s0165-6147(02)00039-1
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Identifiers
ISSN of the journal0165-6147
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