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Monitoring of phagocytic activity in histiocytic cytophagic panniculitis

Zollner, Thomas Matthias
Podda, Maurizio
Ochsendorf, Falk Rudiger
Wolter, Manfred
Kaufmann, Roland
Published in Journal of the American Academy of Dermatology. 2001, vol. 44, no. 1, p. 120-123
Abstract Histiocytic cytophagic panniculitis presents with subcutaneous panniculitis. Histologically, it is characterized by phagocytosis of blood cells in the subcutaneous tissue and bone marrow. One patient with histiocytic cytophagic panniculitis is described in whom hemophagocytosis macrophages and histiocytes was observed histologically and was confirmed in vitro measuring phagocytosis by peripheral blood monocytes by means of chemiluminescence. In vitro measurements of phagocytosis corresponded well with the clinical course. Chemiluminescence for measuring phagocytosis in vitro may be suitable for analyzing disease activity and for testing therapeutic compounds in vitro.
Keywords AdultHistiocytes/pathologyHumansLuminescent MeasurementsMacrophages/pathologyMaleMonitoring, PhysiologicPanniculitis/*pathology*Phagocytosis
PMID: 11148488
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ZOLLNER, Thomas Matthias et al. Monitoring of phagocytic activity in histiocytic cytophagic panniculitis. In: Journal of the American Academy of Dermatology, 2001, vol. 44, n° 1, p. 120-123. doi: 10.1067/mjd.2001.107775

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Deposited on : 2013-09-20

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