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Title

Analysis of TAP2 and HLA-DP gene polymorphism in psoriasis

Authors
Fakler, J. W.
Schmitt-Egenolf, M.
Vejbaesya, S.
Sterry, Wolfram
Eiermann, T. H.
Published in Human Immunology. 1994, vol. 40, no. 4, p. 299-302
Abstract TAP2 is a gene, located between HLA-DP and HLA-DQ, whose products form a transporter molecule involved in endogenous antigen processing. Polymorphic residues have been described in this gene. TAP2 is of particular interest because its involvement in antigen presentation makes it a candidate for a disease susceptibility gene. In psoriasis, two clinical subtypes analogous to the situation in diabetes type I with early onset and family history and type II with later onset and without family history have been described. We have previously shown that type I but not type II psoriasis is associated with the HLA-DRB1*0701/2, -DQA1*0201, -DQB1*0303 haplotype. To investigate whether this haplotype extends to include particular TAP2 and/or DP alleles, we tested the TAP2 and HLA-DP alleles of a control group (n = 199), patients with psoriasis type I (n = 66), and patients with psoriasis type II (n = 35) by hybridization with SSOs. Our data show that there is no significant correlation between TAP2 and/or HLA-DP gene polymorphism and psoriasis type I and/or type II. We conclude that disease association in type I psoriasis is associated with the extended haplotype HLA-B57, -Cw6, -DRB1*0701/2, -DQA1*0201, -DQB1*0303.
Keywords ATP-Binding Cassette Transporters/*geneticsAdultDNA/geneticsHLA-DP Antigens/*geneticsHLA-DQ Antigens/geneticsHLA-DR Antigens/geneticsHLA-DRB1 ChainsHaplotypes/geneticsHumansOligonucleotides/geneticsPolymorphism, Genetic/*geneticsPsoriasis/*genetics
Identifiers
PMID: 8002377
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FAKLER, J. W. et al. Analysis of TAP2 and HLA-DP gene polymorphism in psoriasis. In: Human Immunology, 1994, vol. 40, n° 4, p. 299-302. https://archive-ouverte.unige.ch/unige:29852

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Deposited on : 2013-09-20

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