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Ablative techniques in Psoriasis vulgaris resistant to conventional therapies
|Published in||Dermatologic Surgery. 1999, vol. 25, no. 8, p. 618-621|
|Abstract||BACKGROUND: Treatment of patients with psoriasis vulgaris exhibiting only solitary plaque-stage lesions might become difficult since topical treatments often fail and systemic therapies seem inappropriate. OBJECTIVE: We evaluated the feasibility of ablative techniques in this clinical setting comparing dermatome shaving to the application of an Er:YAG laser. METHODS: Six patients were treated by means of dermatome shaving; in four of these patients additional lesions were ablated utilizing an Er:YAG laser (2 J, 10 Hz, 5 mm spot size). RESULTS: Four of six patients experienced complete clearance of the lesions treated, three of the four patients receiving additional Er:YAG treatment also showed a complete clinical response. CONCLUSION: Our observations document that removal of epidermis and the papillary dermis is effective in treating recalcitrant psoriatic plaques. The Er:YAG laser represents a state-of-the-art device for performing this task. The beneficial effect on skin might be due to clearance of the putative autoantigen along with a considerable part of the potential effector cell population.|
|Keywords||*Debridement — Dermatologic Surgical Procedures — Feasibility Studies — Follow-Up Studies — Humans — *Laser Coagulation — Outcome and Process Assessment (Health Care) — Psoriasis/pathology/*surgery — Skin/pathology|
|BOEHNCKE, Wolf-Henning et al. Ablative techniques in Psoriasis vulgaris resistant to conventional therapies. In: Dermatologic Surgery, 1999, vol. 25, n° 8, p. 618-621. doi: 10.1046/j.1524-4725.1999.99066.x https://archive-ouverte.unige.ch/unige:29835|