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Ablative techniques in Psoriasis vulgaris resistant to conventional therapies

Ochsendorf, Falk Rudiger
Wolter, Manfred
Kaufmann, Roland
Published in Dermatologic surgery. 1999, vol. 25, no. 8, p. 618-621
Abstract BACKGROUND: Treatment of patients with psoriasis vulgaris exhibiting only solitary plaque-stage lesions might become difficult since topical treatments often fail and systemic therapies seem inappropriate. OBJECTIVE: We evaluated the feasibility of ablative techniques in this clinical setting comparing dermatome shaving to the application of an Er:YAG laser. METHODS: Six patients were treated by means of dermatome shaving; in four of these patients additional lesions were ablated utilizing an Er:YAG laser (2 J, 10 Hz, 5 mm spot size). RESULTS: Four of six patients experienced complete clearance of the lesions treated, three of the four patients receiving additional Er:YAG treatment also showed a complete clinical response. CONCLUSION: Our observations document that removal of epidermis and the papillary dermis is effective in treating recalcitrant psoriatic plaques. The Er:YAG laser represents a state-of-the-art device for performing this task. The beneficial effect on skin might be due to clearance of the putative autoantigen along with a considerable part of the potential effector cell population.
Keywords *DebridementDermatologic Surgical ProceduresFeasibility StudiesFollow-Up StudiesHumans*Laser CoagulationOutcome and Process Assessment (Health Care)Psoriasis/pathology/*surgerySkin/pathology
PMID: 10491044
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BOEHNCKE, Wolf-Henning et al. Ablative techniques in Psoriasis vulgaris resistant to conventional therapies. In: Dermatologic surgery, 1999, vol. 25, n° 8, p. 618-621. doi: 10.1046/j.1524-4725.1999.99066.x

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Deposited on : 2013-09-20

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