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Titles listBiologic effects of bacterial superantigens in a xenogeneic transplantation model for psoriasis
Titles listBiologic effects of bacterial superantigens in a xenogeneic transplantation model for psoriasis
Scientific Article
unige:29832 
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Biologic effects of bacterial superantigens in a xenogeneic transplantation model for psoriasis |
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| Author | ||
| Published in | Journal of Investigative Dermatology - Symposium Proceedings. 2001, vol. 6, no. 3, p. 231-232 | |
| Abstract | Both clinical as well as experimental data support the concept of psoriasis being a T-cell-mediated immune disease possibly triggered by bacterial superantigens. Further analysis of its pathogenesis was facilitated by the generation of a xenogeneic transplantation model in which skin from psoriatic patients is grafted onto SCID mice lacking functional B and T cells. Applying this model it was demonstrated that psoriasis can be triggered by bacterial superantigens; this process depends on the presence of immunocytes. Mutated variants of the respective superantigens exhibiting no measurable affinity to HLA class II molecules can function as competitive inhibitors in vivo. | |
| Keywords | Animals — Antigens, Bacterial/*immunology — Disease Models, Animal — Humans — Psoriasis/*immunology/microbiology — Skin Transplantation/*immunology — Superantigens/*immunology — Transplantation, Heterologous | |
| Identifiers | PMID: 11924833 | |
| Full text |
Article - Limited access to UNIGE Other version: http://www.nature.com/jidsp/journal/v6/n3/pdf/5640062a.pdf |
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| Citation (ISO format) | BOEHNCKE, Wolf-Henning. Biologic effects of bacterial superantigens in a xenogeneic transplantation model for psoriasis. In: Journal of Investigative Dermatology - Symposium Proceedings, 2001, vol. 6, n° 3, p. 231-232. https://archive-ouverte.unige.ch/unige:29832 |
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