Biologic effects of bacterial superantigens in a xenogeneic transplantation model for psoriasis

Boehncke, Wolf-Henning

doi:10.1046/j.0022-202x.2001.00042.x

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Title		Biologic effects of bacterial superantigens in a xenogeneic transplantation model for psoriasis
Author		Boehncke, Wolf-Henning
Published in		Journal of Investigative Dermatology - Symposium Proceedings. 2001, vol. 6, no. 3, p. 231-232
Abstract		Both clinical as well as experimental data support the concept of psoriasis being a T-cell-mediated immune disease possibly triggered by bacterial superantigens. Further analysis of its pathogenesis was facilitated by the generation of a xenogeneic transplantation model in which skin from psoriatic patients is grafted onto SCID mice lacking functional B and T cells. Applying this model it was demonstrated that psoriasis can be triggered by bacterial superantigens; this process depends on the presence of immunocytes. Mutated variants of the respective superantigens exhibiting no measurable affinity to HLA class II molecules can function as competitive inhibitors in vivo.
Keywords		Animals — Antigens, Bacterial/immunology — Disease Models, Animal — Humans — Psoriasis/immunology/microbiology — Skin Transplantation/immunology — Superantigens/immunology — Transplantation, Heterologous
Identifiers		DOI: 10.1046/j.0022-202x.2001.00042.x PMID: 11924833
Full text		Article - Limited access to UNIGE Other version: http://www.nature.com/jidsp/journal/v6/n3/pdf/5640062a.pdf
Citation (ISO format)		BOEHNCKE, Wolf-Henning. Biologic effects of bacterial superantigens in a xenogeneic transplantation model for psoriasis. In: Journal of Investigative Dermatology - Symposium Proceedings, 2001, vol. 6, n° 3, p. 231-232. doi: 10.1046/j.0022-202x.2001.00042.x https://archive-ouverte.unige.ch/unige:29832