Scientific article

Biologic effects of bacterial superantigens in a xenogeneic transplantation model for psoriasis

Publication date2001

Both clinical as well as experimental data support the concept of psoriasis being a T-cell-mediated immune disease possibly triggered by bacterial superantigens. Further analysis of its pathogenesis was facilitated by the generation of a xenogeneic transplantation model in which skin from psoriatic patients is grafted onto SCID mice lacking functional B and T cells. Applying this model it was demonstrated that psoriasis can be triggered by bacterial superantigens; this process depends on the presence of immunocytes. Mutated variants of the respective superantigens exhibiting no measurable affinity to HLA class II molecules can function as competitive inhibitors in vivo.

  • Animals
  • Antigens, Bacterial/*immunology
  • Disease Models, Animal
  • Humans
  • Psoriasis/*immunology/microbiology
  • Skin Transplantation/*immunology
  • Superantigens/*immunology
  • Transplantation, Heterologous
Affiliation Not a UNIGE publication
Citation (ISO format)
BOEHNCKE, Wolf-Henning. Biologic effects of bacterial superantigens in a xenogeneic transplantation model for psoriasis. In: The Journal of investigative dermatology symposium proceedings, 2001, vol. 6, n° 3, p. 231–232. doi: 10.1046/j.0022-202x.2001.00042.x
Main files (1)
ISSN of the journal1087-0024

Technical informations

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