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Scientific article
English

Biologic effects of bacterial superantigens in a xenogeneic transplantation model for psoriasis

Publication date2001
Abstract

Both clinical as well as experimental data support the concept of psoriasis being a T-cell-mediated immune disease possibly triggered by bacterial superantigens. Further analysis of its pathogenesis was facilitated by the generation of a xenogeneic transplantation model in which skin from psoriatic patients is grafted onto SCID mice lacking functional B and T cells. Applying this model it was demonstrated that psoriasis can be triggered by bacterial superantigens; this process depends on the presence of immunocytes. Mutated variants of the respective superantigens exhibiting no measurable affinity to HLA class II molecules can function as competitive inhibitors in vivo.

Keywords
  • Animals
  • Antigens, Bacterial/*immunology
  • Disease Models, Animal
  • Humans
  • Psoriasis/*immunology/microbiology
  • Skin Transplantation/*immunology
  • Superantigens/*immunology
  • Transplantation, Heterologous
Affiliation Not a UNIGE publication
Citation (ISO format)
BOEHNCKE, Wolf-Henning. Biologic effects of bacterial superantigens in a xenogeneic transplantation model for psoriasis. In: The Journal of investigative dermatology symposium proceedings, 2001, vol. 6, n° 3, p. 231–232. doi: 10.1046/j.0022-202x.2001.00042.x
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accessLevelRestricted
Identifiers
ISSN of the journal1087-0024
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