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Narrowband UV-B phototherapy in the treatment of cutaneous graft versus host disease

Grundmann-Kollmann, Marcella
Martin, Hans
Ludwig, Ralf J.
Klein, Stefan
Hoelzer, Dieter
Kaufmann, Roland
Podda, Maurizio
Published in Transplantation. 2002, vol. 74, no. 11, p. 1631-1634
Abstract Graft versus host disease (GVHD) is an important problem following allogenic bone marrow transplantation (BMT). The beneficial effects of photochemotherapy with psoralens plus UVA irradiation (PUVA) have been described repeatedly; however, PUVA is limited by a wide range of unwanted effects. A novel improved form of UV-B phototherapy, narrowband UV-B, has been proven to be very effective in T-cell mediated dermatoses. Therefore, we investigated the effect of narrowband UV-B phototherapy (5 times per week) in 10 patients with cutaneous GVHD (grade 2-3) resistant to standard immunosuppressive drugs. It was tolerated well by all patients, and no side effects were observed. Skin lesions showed complete clearance in 7 out of 10 patients within 3 to 5 weeks. 3 patients showed significant improvement of GVHD. We suggest that narrowband UV-B phototherapy is a nonaggressive treatment that may benefit patients with cutaneous GVHD who already take high doses of immunosuppressive drugs.
Keywords AdultDrug ResistanceFemaleGraft vs Host Disease/drug therapy/pathology/*radiotherapyHumansImmunosuppressive Agents/therapeutic useMaleMiddle AgedSkin Diseases/drug therapy/pathology/*radiotherapyTreatment OutcomeUltraviolet Therapy/*methods
PMID: 12490799
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GRUNDMANN-KOLLMANN, Marcella et al. Narrowband UV-B phototherapy in the treatment of cutaneous graft versus host disease. In: Transplantation, 2002, vol. 74, n° 11, p. 1631-1634.

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Deposited on : 2013-09-20

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