Scientific Article
previous document  unige:29818  next document
add to browser collection
Title

Der selektive Cyclooxygenase-2-Inhibitor Celecoxib ist ein sicheres Ausweichpraparat bei Intoleranz gegenuber nichtsteroidalen Antiphlogistika

Authors
Ahlbach, Sandra
Usadel, Klaus-Henning
Kaufmann, Roland
Published in Medizinische Klinik. 2003, vol. 98, no. 5, p. 242-244
Abstract BACKGROUND: Adverse reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) are frequent, and the need to identify a safe alternative drug is a common problem in clinical practice. We assessed the tolerability of the selective cyclooxygenase-2 inhibitor celecoxib in a group of NSAID-sensitive patients. PATIENTS AND METHODS: 77 patients (24 males, 53 females, age 31-80 years) with a history of adverse reactions to NSAIDs underwent standardized skin prick, scratch and patch tests along with oral, placebo-controlled blinded exposure to celecoxib (maximum single dose 200 mg, cumulative daily dose 350 mg). RESULTS: 21 patients had a history of cutaneous reactions only (urticaria), 25 had encountered respiratory symptoms (asthma), 18 reported cutaneous as well as respiratory symptoms, and in 13 patients an anaphylactoid shock occurred. Acetylsalicylic acid triggered symptoms in 38 patients. In 46 cases, several NSAIDs of different chemical groups caused symptoms. Oral challenge with celecoxib was tolerated by all 77 patients without adverse effects. CONCLUSION: This study demonstrates that celecoxib does not have cross-intolerance to NSAIDs. Celecoxib is a safe alternative in subjects with previous adverse reactions to NSAIDs.
Keywords AdultAgedAged, 80 and overAnti-Inflammatory Agents, Non-Steroidal/*adverse effects/therapeutic useCyclooxygenase Inhibitors/adverse effects/*therapeutic useDrug Hypersensitivity/*etiology/prevention & controlFemaleHumansIntradermal TestsMaleMiddle AgedPyrazolesSingle-Blind MethodSulfonamides/adverse effects/*therapeutic use
Identifiers
PMID: 12721666
Full text
Citation
(ISO format)
AHLBACH, Sandra et al. Der selektive Cyclooxygenase-2-Inhibitor Celecoxib ist ein sicheres Ausweichpraparat bei Intoleranz gegenuber nichtsteroidalen Antiphlogistika. In: Medizinische Klinik, 2003, vol. 98, n° 5, p. 242-244. https://archive-ouverte.unige.ch/unige:29818

165 hits

0 download

Update

Deposited on : 2013-09-20

Export document
Format :
Citation style :