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The superantigen exfoliative toxin induces cutaneous lymphocyte-associated antigen expression in peripheral human T lymphocytes
|Published in||Immunology letters. 1996, vol. 49, no. 1-2, p. 111-116|
|Abstract||Several immune-mediated dermatoses including psoriasis and atopic dermatitis can be exacerbated by bacterial infections. Superantigen producing bacteria can be isolated from skin lesions of these dermatoses. Consistent with superantigen effects, skewed T cell receptor variable gene usage has been demonstrated within these lesions. Therefore, the question arises whether superantigen induce a skin-seeking phenotype within peripheral T cells. In this study, we investigated the in vitro influence of the V beta 2-selective superantigen exfoliative toxin from Staphylococcus aureus on the expression of the cutaneous lymphocyte-associated antigen on peripheral T lymphocytes of healthy donors. We demonstrate that exfoliative toxin dramatically upregulates cutaneous lymphocyte-associated antigen expression on T cell receptor V beta 2+ lymphocytes. Up to 69% of V beta 2+ lymphocytes expressed cutaneous lymphocyte-associated antigen after 5 days of in vitro culture. Additionally, exfoliative toxin also increased cutaneous lymphocyte-associated antigen expression in CD3+ T cell receptor V beta 2- lymphocytes indicating a different effect as caused by the superantigen-T cell receptor V beta 2 interaction. Our findings suggest influence of bacterial superantigens on T lymphocyte skin homing in vivo.|
|Keywords||Antigens, Differentiation, T-Lymphocyte — Antigens, Neoplasm — Exfoliatins/*immunology/*pharmacology — Humans — Lymphocyte Activation/drug effects — Membrane Glycoproteins/*biosynthesis — Receptors, Antigen, T-Cell, alpha-beta/physiology — Superantigens/*immunology/*pharmacology — T-Lymphocytes/*drug effects/*metabolism|
|ZOLLNER, Thomas Matthias et al. The superantigen exfoliative toxin induces cutaneous lymphocyte-associated antigen expression in peripheral human T lymphocytes. In: Immunology letters, 1996, vol. 49, n° 1-2, p. 111-116. doi: 10.1016/0165-2478(95)02491-3 https://archive-ouverte.unige.ch/unige:29815|