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Title

The superantigen exfoliative toxin induces cutaneous lymphocyte-associated antigen expression in peripheral human T lymphocytes

Authors
Zollner, Thomas Matthias
Munk, M. E.
Keller, T.
Nuber, V.
Kaufmann, S. H.
Duijvestijn, A. M.
Sterry, Wolfram
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Published in Immunology Letters. 1996, vol. 49, no. 1-2, p. 111-116
Abstract Several immune-mediated dermatoses including psoriasis and atopic dermatitis can be exacerbated by bacterial infections. Superantigen producing bacteria can be isolated from skin lesions of these dermatoses. Consistent with superantigen effects, skewed T cell receptor variable gene usage has been demonstrated within these lesions. Therefore, the question arises whether superantigen induce a skin-seeking phenotype within peripheral T cells. In this study, we investigated the in vitro influence of the V beta 2-selective superantigen exfoliative toxin from Staphylococcus aureus on the expression of the cutaneous lymphocyte-associated antigen on peripheral T lymphocytes of healthy donors. We demonstrate that exfoliative toxin dramatically upregulates cutaneous lymphocyte-associated antigen expression on T cell receptor V beta 2+ lymphocytes. Up to 69% of V beta 2+ lymphocytes expressed cutaneous lymphocyte-associated antigen after 5 days of in vitro culture. Additionally, exfoliative toxin also increased cutaneous lymphocyte-associated antigen expression in CD3+ T cell receptor V beta 2- lymphocytes indicating a different effect as caused by the superantigen-T cell receptor V beta 2 interaction. Our findings suggest influence of bacterial superantigens on T lymphocyte skin homing in vivo.
Keywords Antigens, Differentiation, T-LymphocyteAntigens, NeoplasmExfoliatins/*immunology/*pharmacologyHumansLymphocyte Activation/drug effectsMembrane Glycoproteins/*biosynthesisReceptors, Antigen, T-Cell, alpha-beta/physiologySuperantigens/*immunology/*pharmacologyT-Lymphocytes/*drug effects/*metabolism
Identifiers
PMID: 8964597
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ZOLLNER, Thomas Matthias et al. The superantigen exfoliative toxin induces cutaneous lymphocyte-associated antigen expression in peripheral human T lymphocytes. In: Immunology Letters, 1996, vol. 49, n° 1-2, p. 111-116. https://archive-ouverte.unige.ch/unige:29815

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Deposited on : 2013-09-20

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