Scientific Article
previous document  unige:29815  next document
add to browser collection
Title

The superantigen exfoliative toxin induces cutaneous lymphocyte-associated antigen expression in peripheral human T lymphocytes
Authors
Zollner, Thomas Matthias
Munk, M. E.
Keller, T.
Nuber, V.
Boehncke, Wolf-Henning
Kaufmann, S. H.
Duijvestijn, A. M.
Sterry, Wolfram
show hidden authors show all authors [1 - 9]
Published in Immunology Letters. 1996, vol. 49, no. 1-2, p. 111-116
Abstract Several immune-mediated dermatoses including psoriasis and atopic dermatitis can be exacerbated by bacterial infections. Superantigen producing bacteria can be isolated from skin lesions of these dermatoses. Consistent with superantigen effects, skewed T cell receptor variable gene usage has been demonstrated within these lesions. Therefore, the question arises whether superantigen induce a skin-seeking phenotype within peripheral T cells. In this study, we investigated the in vitro influence of the V beta 2-selective superantigen exfoliative toxin from Staphylococcus aureus on the expression of the cutaneous lymphocyte-associated antigen on peripheral T lymphocytes of healthy donors. We demonstrate that exfoliative toxin dramatically upregulates cutaneous lymphocyte-associated antigen expression on T cell receptor V beta 2+ lymphocytes. Up to 69% of V beta 2+ lymphocytes expressed cutaneous lymphocyte-associated antigen after 5 days of in vitro culture. Additionally, exfoliative toxin also increased cutaneous lymphocyte-associated antigen expression in CD3+ T cell receptor V beta 2- lymphocytes indicating a different effect as caused by the superantigen-T cell receptor V beta 2 interaction. Our findings suggest influence of bacterial superantigens on T lymphocyte skin homing in vivo.
Keywords Antigens, Differentiation, T-Lymphocyte — Antigens, Neoplasm — Exfoliatins/*immunology/*pharmacology — Humans — Lymphocyte Activation/drug effects — Membrane Glycoproteins/*biosynthesis — Receptors, Antigen, T-Cell, alpha-beta/physiology — Superantigens/*immunology/*pharmacology — T-Lymphocytes/*drug effects/*metabolism
Identifiers
PMID: 8964597
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://ac.els-cdn.com/0165247895024913/1-s2.0-0165247895024913-main.pdf?_tid=d6c55512-0bd4-11e3-b63d-00000aab0f01&acd...
Citation
(ISO format) 		ZOLLNER, Thomas Matthias et al. The superantigen exfoliative toxin induces cutaneous lymphocyte-associated antigen expression in peripheral human T lymphocytes. In: Immunology Letters, 1996, vol. 49, n° 1-2, p. 111-116. https://archive-ouverte.unige.ch/unige:29815

218 hits

0 download

Contact an author

Update request

Update

Deposited on : 2013-09-20

Export document
Format :
Citation style :