en
Scientific article
English

Therapy of psoriasis in childhood and adolescence - a German expert consensus

Published inJournal der Deutschen Dermatologischen Gesellschaft, vol. 9, no. 10, p. 815-823
Publication date2011
Abstract

Psoriasis of childhood shows an annual prevalence of 0.71 % and accordingly has to be regarded as a frequent chronic inflammatory skin disorder of this age. The impact on the quality of life as well as development of the afflicted children and their parents is evident. On the other side, therapy is demanding with regard to the specific juvenile metabolism, physical development and skin penetration of topical drugs. Long-term treatment at an early age has to be critically judged regarding the chronicity of the disease. Topical corticosteroids, alternatively dithranol may be used first-line, followed by vitamin D derivatives. A combination with UV-light, preferably UV-B, has to be decided on an individual basis. Systemic treatment may be initiated in recalcitrant disease with methotrexate and cyclosporine where long-term experience is available from juvenile rheumatology and transplantation medicine. Alternatively fumaric acid esters or retinoids are available. Rehabilitation procedures will help the children and their parents to cope with the disease and its treatment. The different treatment options are presented here as a German expert consensus, as clinical studies are hardly available and only a few therapeutics are licensed for this age. In any case the therapy has to be individually planned and decided together with the patients and their parents to gain maximal safety, comfort and success.

Keywords
  • Administration, Oral
  • Administration, Topical
  • Adolescent
  • Adrenal Cortex Hormones/*administration & dosage/adverse effects/pharmacokinetics
  • Anthralin/*administration & dosage/adverse effects/pharmacokinetics
  • Anti-Inflammatory Agents/*administration & dosage/adverse
  • Effects/pharmacokinetics
  • Child
  • Cross-Sectional Studies
  • Dermatologic Agents/*administration & dosage/adverse effects/pharmacokinetics
  • Germany
  • Humans
  • Psoriasis/diagnosis/*drug therapy/epidemiology
  • Skin Absorption/drug effects
  • Skin Care/methods
  • Urea/administration & dosage/adverse effects/pharmacokinetics
Affiliation Not a UNIGE publication
Citation (ISO format)
STICHERLING, Michael et al. Therapy of psoriasis in childhood and adolescence - a German expert consensus. In: Journal der Deutschen Dermatologischen Gesellschaft, 2011, vol. 9, n° 10, p. 815–823. doi: 10.1111/j.1610-0387.2011.07668.x
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accessLevelRestricted
Identifiers
ISSN of the journal1610-0379
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