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Therapy of psoriasis in childhood and adolescence - a German expert consensus

Sticherling, Michael
Augustin, Matthias
Christophers, Enno
Domm, Silja
Gollnick, Harald
Reich, Kristian
Mrowietz, Ulrich
Published in Journal der Deutschen Dermatologischen Gesellschaft. 2011, vol. 9, no. 10, p. 815-823
Abstract Psoriasis of childhood shows an annual prevalence of 0.71 % and accordingly has to be regarded as a frequent chronic inflammatory skin disorder of this age. The impact on the quality of life as well as development of the afflicted children and their parents is evident. On the other side, therapy is demanding with regard to the specific juvenile metabolism, physical development and skin penetration of topical drugs. Long-term treatment at an early age has to be critically judged regarding the chronicity of the disease. Topical corticosteroids, alternatively dithranol may be used first-line, followed by vitamin D derivatives. A combination with UV-light, preferably UV-B, has to be decided on an individual basis. Systemic treatment may be initiated in recalcitrant disease with methotrexate and cyclosporine where long-term experience is available from juvenile rheumatology and transplantation medicine. Alternatively fumaric acid esters or retinoids are available. Rehabilitation procedures will help the children and their parents to cope with the disease and its treatment. The different treatment options are presented here as a German expert consensus, as clinical studies are hardly available and only a few therapeutics are licensed for this age. In any case the therapy has to be individually planned and decided together with the patients and their parents to gain maximal safety, comfort and success.
Keywords Administration, OralAdministration, TopicalAdolescentAdrenal Cortex Hormones/*administration & dosage/adverse effects/pharmacokineticsAnthralin/*administration & dosage/adverse effects/pharmacokineticsAnti-Inflammatory Agents/*administration & dosage/adverseEffects/pharmacokineticsChildCross-Sectional StudiesDermatologic Agents/*administration & dosage/adverse effects/pharmacokineticsGermanyHumansPsoriasis/diagnosis/*drug therapy/epidemiologySkin Absorption/drug effectsSkin Care/methodsUrea/administration & dosage/adverse effects/pharmacokinetics
PMID: 21585653
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STICHERLING, Michael et al. Therapy of psoriasis in childhood and adolescence - a German expert consensus. In: Journal der Deutschen Dermatologischen Gesellschaft, 2011, vol. 9, n° 10, p. 815-823. doi: 10.1111/j.1610-0387.2011.07668.x

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Deposited on : 2013-09-20

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