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The 'psoriatic march': a concept of how severe psoriasis may drive cardiovascular comorbidity

Tobin, Anne-Marie
Kirby, Brian
Published in Experimental dermatology. 2011, vol. 20, no. 4, p. 303-307
Abstract There is increasing awareness that psoriasis is more than 'skin deep'. Several recent reviews focussed on biomarkers indicating the systemic dimension of psoriasis and the aspect of comorbidity psoriasis shares with other chronic inflammatory diseases, such as Crohn's disease and rheumatoid arthritis. Of emerging significance is the relationship to cardiovascular disease, as this contributes substantially to the patients' increased mortality. In this viewpoint, we examine currently available evidence favouring the concept of a causal link between psoriasis and cardiovascular disease: systemic inflammation may cause insulin resistance, which in turn triggers endothelial cell dysfunction, leading to atherosclerosis and finally myocardial infarction or stroke. While this 'psoriatic march' is not yet formally proven, it raises clinically and academically relevant questions, and gains support by recent observations of numerous investigators.
Keywords Cardiovascular Diseases/*etiologyChronic DiseaseCytokines/physiologyDisease ProgressionEndothelial Cells/pathology/physiologyHumansInflammation/*complicationsInsulin Resistance/physiologyPsoriasis/*complications
PMID: 21410760
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BOEHNCKE, Wolf-Henning et al. The 'psoriatic march': a concept of how severe psoriasis may drive cardiovascular comorbidity. In: Experimental dermatology, 2011, vol. 20, n° 4, p. 303-307. doi: 10.1111/j.1600-0625.2011.01261.x

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Deposited on : 2013-09-20

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