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Title

Platelet P-selectin reflects a state of cutaneous inflammation: possible application to monitor treatment efficacy in psoriasis
Authors
Garbaraviciene, Jurate
Diehl, Sandra
Varwig, Domenica
Bylaite, Matilda
Ackermann, Hanns
Ludwig, Ralf J.
Boehncke, Wolf-Henning
Published in Experimental Dermatology. 2010, vol. 19, no. 8, p. 736-741
Abstract Haemostasis-maintaining platelets are also recognized as important modulators in the regulation of immune response. Activated platelets expressing P-selectin (CD62P) are involved in the extravasation of leucocytes. This study evaluated platelet P-selectin expression as a biomarker for cutaneous inflammation. P-selectin expression was assessed by flow cytometry in 147 successive patients suffering from an inflammatory or infectious skin condition at the day of admission for in-patient treatment as well as a day prior to demission. Forty-one patients admitted for allergy testing served as controls. A commercially available ELISA was used in 17 patients to determine soluble P-selectin in the plasma. In patients with psoriasis, the Psoriasis Area and Severity Index (PASI) was documented as a measure for disease severity. We observed a significant increase in platelet P-selectin expression in patients with inflammatory or infectious disorders, when compared to the control group (3,01% vs. 1,46%; P < 0.000001). Successful treatment resulted in a significant decrease in P-selectin expression to the level of the control group. In the case of psoriasis (n = 47), we found highly significant correlation between P-selectin and PASI (r = 0.51; P < 0.000001), as well as between the change in the PASI and the change in P-selectin expression (r = 0.4; P = 0.006). Platelet P-selectin expression as determined by flow cytometry correlated well with the results of soluble P-selectin, determined by ELISA (r = 0.63; P < 0.01). Thus, platelet P-selectin expression may be used as an efficacy biomarker to monitor treatment success in psoriasis. As platelet P-selectin correlates with soluble P-selectin in patient plasma, which can be measured by ELISA, the latter is feasible also for routine use.
Keywords Anti-Inflammatory Agents/therapeutic use — Biological Markers/blood — Blood Platelets/*metabolism — C-Reactive Protein/metabolism — Case-Control Studies — Dermatitis/*blood — Humans — P-Selectin/*blood — Phototherapy — Psoriasis/*blood/diagnosis/*therapy — Severity of Illness Index — Treatment Outcome
Identifiers
PMID: 20482619
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Other version: http://onlinelibrary.wiley.com/store/10.1111/j.1600-0625.2010.01095.x/asset/j.1600-0625.2010.01095.x.pdf?v=1&t=hkp70x...
Citation
(ISO format) 		GARBARAVICIENE, Jurate et al. Platelet P-selectin reflects a state of cutaneous inflammation: possible application to monitor treatment efficacy in psoriasis. In: Experimental Dermatology, 2010, vol. 19, n° 8, p. 736-741. doi: 10.1111/j.1600-0625.2010.01095.x https://archive-ouverte.unige.ch/unige:29778

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Deposited on : 2013-09-20

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