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Psoriasis--a systemic inflammatory disorder: clinic, pathogenesis and therapeutic perspectives

Sterry, Wolfram
Published in Journal der Deutschen Dermatologischen Gesellschaft. 2009, vol. 7, no. 11, p. 946-952
Abstract Psoriasis has seen a dramatic change in its perception by dermatologists as well as other medical specialties. Its well-recognized association with several other diseases makes a complete switch in its management necessary. This review summarizes current epidemiological data on the comorbidities of psoriasis. Subsequently, the evidence for insulin resistance as a cause for endothelial cell dysfunction with its relevant pathogenetic link to the development of cardiovascular comorbidity is discussed. Based on these novel insights, we propose a possible state-of-the-art approach towards comprehensive psoriasis management.
Keywords Anti-Inflammatory Agents/*therapeutic useDermatologic Agents/*therapeutic useHumansInflammation/complications/*diagnosis/*drug therapyPsoriasis/complications/*diagnosis/*drug therapy
PMID: 19341429
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BOEHNCKE, Wolf-Henning, STERRY, Wolfram. Psoriasis--a systemic inflammatory disorder: clinic, pathogenesis and therapeutic perspectives. In: Journal der Deutschen Dermatologischen Gesellschaft, 2009, vol. 7, n° 11, p. 946-952. doi: 10.1111/j.1610-0387.2009.07083.x

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Deposited on : 2013-09-20

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