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Die Rolle bakterieller Superantigene in der Pathophysiologie der Haut

Zollner, Thomas Matthias
Published in Der Hautarzt. 1999, vol. 50, no. 2, p. 91-97
Abstract In contrast to conventional antigens, bacterial superantigens activate a large percentage of an organism's total T-cell repertoire. This has clinical implications particularly in the case of infections with Gram-positive bacteria. Unravelling the molecular mechanisms of superantigen-mediated T-cell activation has yielded new insights in the pathogenesis of a number of diseases, in the field of dermatology namely atopic dermatitis and psoriasis. Moreover, therapeutic applications of superantigens have begun to emerge.
Keywords Dermatitis, Atopic/immunology/therapyGram-Positive Bacteria/immunologyHumansLymphocyte Activation/immunologyPsoriasis/immunology/therapySkin Diseases/*immunology/therapySuperantigens/*immunology/therapeutic useT-Lymphocytes/immunology
PMID: 10097950
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BOEHNCKE, Wolf-Henning, ZOLLNER, Thomas Matthias. Die Rolle bakterieller Superantigene in der Pathophysiologie der Haut. In: Der Hautarzt, 1999, vol. 50, n° 2, p. 91-97. doi: 10.1007/s001050050870

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Deposited on : 2013-09-20

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