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Scientific article
English

Die Rolle bakterieller Superantigene in der Pathophysiologie der Haut

Other titleThe role of bacterial superantigens in pathophysiology of the skin
Published inDer Hautarzt, vol. 50, no. 2, p. 91-97
Publication date1999
Abstract

In contrast to conventional antigens, bacterial superantigens activate a large percentage of an organism's total T-cell repertoire. This has clinical implications particularly in the case of infections with Gram-positive bacteria. Unravelling the molecular mechanisms of superantigen-mediated T-cell activation has yielded new insights in the pathogenesis of a number of diseases, in the field of dermatology namely atopic dermatitis and psoriasis. Moreover, therapeutic applications of superantigens have begun to emerge.

Keywords
  • Dermatitis, Atopic/immunology/therapy
  • Gram-Positive Bacteria/immunology
  • Humans
  • Lymphocyte Activation/immunology
  • Psoriasis/immunology/therapy
  • Skin Diseases/*immunology/therapy
  • Superantigens/*immunology/therapeutic use
  • T-Lymphocytes/immunology
Affiliation Not a UNIGE publication
Citation (ISO format)
BOEHNCKE, Wolf-Henning, ZOLLNER, Thomas Matthias. Die Rolle bakterieller Superantigene in der Pathophysiologie der Haut. In: Der Hautarzt, 1999, vol. 50, n° 2, p. 91–97. doi: 10.1007/s001050050870
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ISSN of the journal0017-8470
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