en
Scientific article
English

Calcipotriol solution for the treatment of scalp psoriasis: evaluation of efficacy, safety and acceptance in 3,396 patients

Published inDermatology, vol. 203, no. 2, p. 153-156
Publication date2001
Abstract

BACKGROUND: Psoriasis of the scalp is a very common disease, cosmetically disturbing and therapeutically difficult to manage. OBJECTIVE: The aim of our study was to investigate the efficacy, safety and cosmetic acceptance of calcipotriol solution in a large number of patients with mild to moderate scalp psoriasis and to compare this treatment with previous therapies used. METHODS: In this multicentre prospective observational cohort study 3,396 patients were treated with calcipotriol solution (50 microg/ml) twice daily over an 8-week period either alone or in combination with other treatments. The psoriasis scalp severity index (PSSI) and investigator/patient global assessment were used for the evaluation of clinical response. RESULTS: All psoriasis severity parameters measured were reduced with a significant decrease in PSSI scores from 18.4 to 5.6 after 8 weeks of therapy (p < 0.001). About 80% of the patients showed very good or good clinical improvement. Combination of calcipotriol solution with other treatment modalities e.g. corticosteroids or salicylic acid, showed an increased treatment response. In only 2.4% of the patients side effects occurred (e.g. irritation). CONCLUSION: Calcipotriol solution is an effective, safe, well-tolerated and cosmetically acceptable treatment modality. By patients and physicians, this treatment was found to be a valuable supplement to previously available and established treatments for scalp psoriasis.

Keywords
  • Adult
  • Calcitriol/*analogs & derivatives/*therapeutic use
  • Cohort Studies
  • Combined Modality Therapy
  • Dermatologic Agents/*therapeutic use
  • Drug Therapy, Combination
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Pruritus/chemically induced
  • Psoriasis/*drug therapy
  • Salicylic Acid/therapeutic use
  • Scalp Dermatoses/*drug therapy
  • Severity of Illness Index
  • Skin/drug effects/pathology
  • Solutions
  • Treatment Outcome
  • Ultraviolet Therapy
Affiliation Not a UNIGE publication
Citation (ISO format)
THACI, Diamant et al. Calcipotriol solution for the treatment of scalp psoriasis: evaluation of efficacy, safety and acceptance in 3,396 patients. In: Dermatology, 2001, vol. 203, n° 2, p. 153–156.
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ISSN of the journal1018-8665
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