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Calcipotriol solution for the treatment of scalp psoriasis: evaluation of efficacy, safety and acceptance in 3,396 patients

Thaci, Diamant
Daiber, W.
Kaufmann, Roland
Published in Dermatology. 2001, vol. 203, no. 2, p. 153-156
Abstract BACKGROUND: Psoriasis of the scalp is a very common disease, cosmetically disturbing and therapeutically difficult to manage. OBJECTIVE: The aim of our study was to investigate the efficacy, safety and cosmetic acceptance of calcipotriol solution in a large number of patients with mild to moderate scalp psoriasis and to compare this treatment with previous therapies used. METHODS: In this multicentre prospective observational cohort study 3,396 patients were treated with calcipotriol solution (50 microg/ml) twice daily over an 8-week period either alone or in combination with other treatments. The psoriasis scalp severity index (PSSI) and investigator/patient global assessment were used for the evaluation of clinical response. RESULTS: All psoriasis severity parameters measured were reduced with a significant decrease in PSSI scores from 18.4 to 5.6 after 8 weeks of therapy (p < 0.001). About 80% of the patients showed very good or good clinical improvement. Combination of calcipotriol solution with other treatment modalities e.g. corticosteroids or salicylic acid, showed an increased treatment response. In only 2.4% of the patients side effects occurred (e.g. irritation). CONCLUSION: Calcipotriol solution is an effective, safe, well-tolerated and cosmetically acceptable treatment modality. By patients and physicians, this treatment was found to be a valuable supplement to previously available and established treatments for scalp psoriasis.
Keywords AdultCalcitriol/*analogs & derivatives/*therapeutic useCohort StudiesCombined Modality TherapyDermatologic Agents/*therapeutic useDrug Therapy, CombinationFemaleHumansMaleMiddle AgedProspective StudiesPruritus/chemically inducedPsoriasis/*drug therapySalicylic Acid/therapeutic useScalp Dermatoses/*drug therapySeverity of Illness IndexSkin/drug effects/pathologySolutionsTreatment OutcomeUltraviolet Therapy
PMID: 11586015
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THACI, Diamant et al. Calcipotriol solution for the treatment of scalp psoriasis: evaluation of efficacy, safety and acceptance in 3,396 patients. In: Dermatology, 2001, vol. 203, n° 2, p. 153-156.

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Deposited on : 2013-09-20

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