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Psoriasis and bacterial superantigens--formal or causal correlation?

Published in Trends in microbiology. 1996, vol. 4, no. 12, p. 485-489
Abstract Superantigens have recently been identified as candidates for triggering crucial events in the development of psoriasis. Seemingly contradictory observations may complement each other when discussed in the context of the concept of an effector cell cascade initiated by bacterial superantigens that eventually brings about disruption of peripheral tolerance of a CD8+ T-cell subset.
Keywords AllelesAnimalsAntigens, Bacterial/*immunology/physiologyCD8-Positive T-Lymphocytes/immunologyExotoxins/physiologyHistocompatibility Antigens Class I/immunologyHistocompatibility Antigens Class II/genetics/immunologyHumansIntercellular Adhesion Molecule-1/physiologyMiceMice, SCIDPsoriasis/*etiology/immunology/microbiologyReceptors, Antigen, T-Cell, alpha-beta/physiologySkin/immunologySkin TransplantationStreptococcus/chemistrySuperantigens/*immunologyT-Lymphocyte Subsets/immunology
PMID: 9004406
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BOEHNCKE, Wolf-Henning. Psoriasis and bacterial superantigens--formal or causal correlation?. In: Trends in microbiology, 1996, vol. 4, n° 12, p. 485-489. doi: 10.1016/s0966-842x(97)82910-1

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Deposited on : 2013-09-20

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