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Scientific article
English

Differential expression of adhesion molecules on infiltrating cells in inflammatory dermatoses

Published inJournal of the American Academy of Dermatology, vol. 26, no. 6, p. 907-913
Publication date1992
Abstract

BACKGROUND: Adhesion molecules and their ligands are involved in coordination of the activities of the immune system. OBJECTIVE: To evaluate whether adhesion molecules are relevant in the pathogenesis of inflammatory dermatoses, we analyzed the expression pattern of many of these molecules. METHODS: The expression of 10 members of the integrin and immunoglobulin superfamilies was mapped by means of immunohistochemical techniques in biopsy specimens of psoriasis (n = 15), pityriasis lichenoides (n = 11), parapsoriasis en plaques (n = 11), contact dermatitis (n = 7), and lichen planus (n = 5). RESULTS: In all investigated skin diseases, almost every infiltrating cell expressed lymphocyte function-associated antigens 1 and 3 as well as very late activation (VLA) antigens 4 and 5. The subepidermal infiltrate differed with regard to the expression of VLA-1, VLA-3, and VLA-6, which was high in lichen planus and moderate or absent in the other dermatoses. The intraepidermal lymphocytes in psoriasis and pityriasis lichenoides were VLA-1 positive, whereas the subepidermal infiltrate lacked this marker. CONCLUSION: The differential upregulation of adhesion molecules in the mononuclear infiltrate and on keratinocytes demonstrates their importance in the pathogenesis of cutaneous inflammation.

Keywords
  • Antigens, Differentiation
  • Cell Adhesion Molecules/*analysis
  • Dermatitis/*immunology/pathology
  • Humans
  • Immunoenzyme Techniques
  • Keratinocytes/*immunology/ultrastructure
Affiliation Not a UNIGE publication
Citation (ISO format)
BOEHNCKE, Wolf-Henning et al. Differential expression of adhesion molecules on infiltrating cells in inflammatory dermatoses. In: Journal of the American Academy of Dermatology, 1992, vol. 26, n° 6, p. 907–913.
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ISSN of the journal0190-9622
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