en
Scientific article
English

Psoriasis-SCID-Maus-Modell

Other titlePsoriasis SCID-mouse model
Published inDer Hautarzt, vol. 57, no. 7, p. 603-609
Publication date2006
Abstract

Psoriasis is characterized by a complex phenotype and pathogenesis along with polygenic determination. Several psoriasis animal models have only been able to incompletely reproduce the disease. A xenogeneic transplantation approach, grafting skin from psoriatic patients onto mice with a severe combined immunodeficiency (SCID), was the first to meet the criteria for a psoriasis model. During the last 10 years, this psoriasis SCID-mouse model not only allowed telling experiments focusing on pathogenetic aspects, but also proved being a powerful tool for drug discovery with a good predictive value.

Keywords
  • Animals
  • Dermatologic Agents/therapeutic use
  • Disease Models, Animal
  • Humans
  • Mice
  • Mice, SCID
  • Phenotype
  • *Psoriasis/drug therapy/etiology/genetics/immunology/pathology
  • Severe Combined Immunodeficiency
  • Skin/pathology
  • Skin Transplantation
  • Transplantation, Heterologous
Affiliation Not a UNIGE publication
Citation (ISO format)
PFEFFER, Jeannette, KAUFMANN, Roland, BOEHNCKE, Wolf-Henning. Psoriasis-SCID-Maus-Modell. In: Der Hautarzt, 2006, vol. 57, n° 7, p. 603–609. doi: 10.1007/s00105-005-0990-x
Main files (1)
Article
accessLevelRestricted
Identifiers
ISSN of the journal0017-8470
542views
1downloads

Technical informations

Creation09/20/2013 4:48:10 PM
First validation09/20/2013 4:48:10 PM
Update time03/14/2023 8:24:48 PM
Status update03/14/2023 8:24:48 PM
Last indexation02/12/2024 8:31:11 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack