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Pfeffer, Jeannette
Kaufmann, Roland
Published in Der Hautarzt. 2006, vol. 57, no. 7, p. 603-609
Abstract Psoriasis is characterized by a complex phenotype and pathogenesis along with polygenic determination. Several psoriasis animal models have only been able to incompletely reproduce the disease. A xenogeneic transplantation approach, grafting skin from psoriatic patients onto mice with a severe combined immunodeficiency (SCID), was the first to meet the criteria for a psoriasis model. During the last 10 years, this psoriasis SCID-mouse model not only allowed telling experiments focusing on pathogenetic aspects, but also proved being a powerful tool for drug discovery with a good predictive value.
Keywords AnimalsDermatologic Agents/therapeutic useDisease Models, AnimalHumansMiceMice, SCIDPhenotype*Psoriasis/drug therapy/etiology/genetics/immunology/pathologySevere Combined ImmunodeficiencySkin/pathologySkin TransplantationTransplantation, Heterologous
PMID: 16028077
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PFEFFER, Jeannette, KAUFMANN, Roland, BOEHNCKE, Wolf-Henning. Psoriasis-SCID-Maus-Modell. In: Der Hautarzt, 2006, vol. 57, n° 7, p. 603-609. doi: 10.1007/s00105-005-0990-x

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Deposited on : 2013-09-20

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