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Psoriasis-SCID-Maus-Modell

Autre titrePsoriasis SCID-mouse model
Publié dansDer Hautarzt, vol. 57, no. 7, p. 603-609
Date de publication2006
Résumé

Psoriasis is characterized by a complex phenotype and pathogenesis along with polygenic determination. Several psoriasis animal models have only been able to incompletely reproduce the disease. A xenogeneic transplantation approach, grafting skin from psoriatic patients onto mice with a severe combined immunodeficiency (SCID), was the first to meet the criteria for a psoriasis model. During the last 10 years, this psoriasis SCID-mouse model not only allowed telling experiments focusing on pathogenetic aspects, but also proved being a powerful tool for drug discovery with a good predictive value.

Mots-clés
  • Animals
  • Dermatologic Agents/therapeutic use
  • Disease Models, Animal
  • Humans
  • Mice
  • Mice, SCID
  • Phenotype
  • *Psoriasis/drug therapy/etiology/genetics/immunology/pathology
  • Severe Combined Immunodeficiency
  • Skin/pathology
  • Skin Transplantation
  • Transplantation, Heterologous
Structure d'affiliation Pas une publication de l'UNIGE
Citation (format ISO)
PFEFFER, Jeannette, KAUFMANN, Roland, BOEHNCKE, Wolf-Henning. Psoriasis-SCID-Maus-Modell. In: Der Hautarzt, 2006, vol. 57, n° 7, p. 603–609. doi: 10.1007/s00105-005-0990-x
Fichiers principaux (1)
Article
accessLevelRestricted
Identifiants
ISSN du journal0017-8470
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Création20.09.2013 16:48:10
Première validation20.09.2013 16:48:10
Heure de mise à jour14.03.2023 20:24:48
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