Scientific Article
previous document  unige:29721  next document
add to browser collection

Vertraglichkeit des selektiven Cyclooxygenase-2-Inhibitors Rofecoxib bei Intoleranz gegenuber nicht-steroidalen Antiphlogistika

Zollner, Thomas Matthias
Ahlbach, Sandra
Kaufmann, Roland
Published in Deutsche Medizinische Wochenschrift. 2001, vol. 126, no. 14, p. 386-388
Abstract BACKGROUND AND OBJECTIVE: Pseudoallergic reactions triggered by nonsteroidal anti-inflammatory drugs (NSAIDs) are common and caused by inhibition of the enzyme cyclooxygenase-1, whereas their therapeutic effects are mediated by inhibition of cyclooxygenase-2. This study analyzed the tolerability of the selective cyclooxygenase-2-inhibitor rofecoxib in patients who encountered pseudoallergic reactions to NSAIDs. PATIENTS AND METHODS: 37 patients (12 males, 25 females, mean age 35 years [15-75 years]) with a history of pseudoallergic reactions to NSAIDs underwent standardized skin prick, scratch and patch tests along with oral placebo-controlled blinded exposure to rofecoxib (maximum single dose 12.5 mg, cumulative dose 25 mg). RESULTS: 23 patients had skin reactions, 4 times respiratory symptoms were documented, and in 10 cases cutaneous as well as respiratory symptoms were reported. Salicylic acid was identified as the most common trigger for a pseudoallergic reaction (n = 28). In 9 cases several non-steroidal antiphlogistics of different chemical groups caused symptoms. All skin tests showed negative results. Oral challenge with rofecoxib was tolerated by all 37 patients without adverse effects. CONCLUSION: Given the high incidence of pseudoallergic reactions to NSAIDs the use of selective cyclooxygenase-2-inhibitors represents a therapeutic alternative as well as a means of prevention of the described reactions.
Keywords AdolescentAdultAged*Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/adverse effects*Cyclooxygenase Inhibitors/administration & dosage/adverse effectsDrug Eruptions/diagnosis/etiology/prevention & controlDrug Hypersensitivity/diagnosis/*etiology/prevention & controlFemaleHumans*Lactones/administration & dosage/adverse effectsMaleMiddle AgedPlacebosSkin TestsSulfones
PMID: 11332239
Full text
This document has no fulltext available yet, but you can contact its author by using the form below.
(ISO format)
ZOLLNER, Thomas Matthias et al. Vertraglichkeit des selektiven Cyclooxygenase-2-Inhibitors Rofecoxib bei Intoleranz gegenuber nicht-steroidalen Antiphlogistika. In: Deutsche Medizinische Wochenschrift, 2001, vol. 126, n° 14, p. 386-388. doi: 10.1055/s-2001-12640

427 hits

0 download


Deposited on : 2013-09-20

Export document
Format :
Citation style :