en
Scientific article
English

Structural requirements of heparin and related molecules to exert a multitude of anti-inflammatory activities

Published inMini-reviews in medical chemistry, vol. 6, no. 9, p. 1009-1023
Publication date2006
Abstract

Chronic inflammatory diseases are common and still remain a therapeutic challenge for both efficacy and safety reasons. Hence, novel therapeutics addressing these issues would for example improve treatment of severe diseases such as psoriasis, rheumatoid arthritis, inflammatory bowel disease and multiple sclerosis. Inappropriate leukocyte homing to the affected compartments is a common feature of these diseases. Heparin and related polysaccharides have been shown to interfere with leukocyte homing through a variety of effects distinct from their anticoagulant properties. In this review, data on heparin as an anti-inflammatory agent are presented. In addition, structure-activity requirements for the anti-inflammatory properties of heparin are discussed, which should aid the drug development based on structurally modified heparin or other sulfated carbohydrates for treatment of inflammatory diseases.

Keywords
  • Anti-Inflammatory Agents/*chemistry/*pharmacology
  • Heparin/*chemistry/*pharmacology
  • Molecular Structure
  • Structure-Activity Relationship
Affiliation Not a UNIGE publication
Citation (ISO format)
LUDWIG, Ralf J., ALBAN, Susanne, BOEHNCKE, Wolf-Henning. Structural requirements of heparin and related molecules to exert a multitude of anti-inflammatory activities. In: Mini-reviews in medical chemistry, 2006, vol. 6, n° 9, p. 1009–1023.
Identifiers
ISSN of the journal1389-5575
467views
0downloads

Technical informations

Creation09/20/2013 4:32:53 PM
First validation09/20/2013 4:32:53 PM
Update time03/14/2023 8:24:43 PM
Status update03/14/2023 8:24:43 PM
Last indexation01/16/2024 2:09:03 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack