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Article scientifique
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Safety and efficacy of alefacept in elderly patients and other special populations

Publié dansJournal of drugs in dermatology, vol. 4, no. 6, p. 718-724
Date de publication2005
Résumé

BACKGROUND: The safety of biologic agents for psoriasis treatment is of particular importance in patient groups at higher risk for adverse events. We assessed the safety and efficacy of alefacept in elderly, obese, and diabetic patients with moderate to severe chronic plaque psoriasis by integrating data from phase 2 and 3 clinical studies and their extensions. OBSERVATIONS: Ninety-nine elderly, 652 obese, and 122 diabetic patients received at least 1 course of alefacept. In each cohort, accidental injury, headache, and pharyngitis were among the most common adverse events; infections were primarily common colds; and malignancies were mostly skin carcinomas. No opportunistic infections were reported. Safety was maintained over repeated courses. The safety profile of alefacept in each cohort was consistent with that of the overall population; however, additional data are needed to confirm our findings in the elderly and diabetic subgroups in the later courses due to the limited sample sizes. In course 1, 24% to 33% of patients achieved 75% or greater improvement in Psoriasis Area and Severity Index (PASI) at any time, with further enhancement of benefit with subsequent courses (eg, course 3, 41% to 58%). CONCLUSIONS: Alefacept was well-tolerated and effective in elderly, obese, and diabetic patients with psoriasis.

Mots-clés
  • Age Factors
  • Aged
  • Cholelithiasis/epidemiology
  • Chronic Disease
  • Comorbidity
  • Dermatologic Agents/administration & dosage/adverse effects/*therapeutic use
  • Diabetes Mellitus/epidemiology
  • Drug Administration Schedule
  • Humans
  • Injections, Intramuscular
  • Injections, Intravenous
  • Multicenter Studies as Topic
  • Obesity/epidemiology
  • Psoriasis/drug therapy
  • Randomized Controlled Trials as Topic
  • Recombinant Fusion Proteins/administration & dosage/adverse effects/*therapeutic
  • use
  • Severity of Illness Index
  • Time Factors
  • Treatment Outcome
Structure d'affiliation Pas une publication de l'UNIGE
Citation (format ISO)
GOTTLIEB, Alice B., BOEHNCKE, Wolf-Henning, DARIF, Mohamed. Safety and efficacy of alefacept in elderly patients and other special populations. In: Journal of drugs in dermatology, 2005, vol. 4, n° 6, p. 718–724.
Identifiants
ISSN du journal1545-9616
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Création20.09.2013 16:32:52
Première validation20.09.2013 16:32:52
Heure de mise à jour14.03.2023 20:24:42
Changement de statut14.03.2023 20:24:42
Dernière indexation16.01.2024 02:08:58
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