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Scientific article
English

Primary subcutaneous leiomyosarcoma exhibiting the characteristic immunophenotype positive for vimentin and desmin

Published inThe Journal of dermatologic surgery and oncology, vol. 20, no. 8, p. 541-543
Publication date1994
Abstract

BACKGROUND: Primary subcutaneous leiomyosarcoma is a rare neoplasm composed of plump, elongated spindle cells arranged in interweaving fascicles. OBJECTIVE: Differential diagnosis might be facilitated by the use of immunohistochemistry. METHODS: A case of subcutaneous leiomyosarcoma was investigated histologically on paraffin-embedded tissue and immunohistochemistry was performed following standard procedures. RESULTS: The case reported exhibited light microscopic features and an immunophenotype characteristic of leiomyosarcoma. However, the intermediate filament desmin could only be found on a small number of tumor cells. CONCLUSION: Expression of these markers might vary considerably and immunoperoxidase stainings need to be carefully evaluated. Utilization of several antibodies directed against different desmin epitopes might be advantageous.

Keywords
  • Aged
  • Desmin/*analysis
  • Diagnosis, Differential
  • Female
  • Humans
  • Immunohistochemistry
  • Immunophenotyping
  • Keratins/analysis
  • Leiomyosarcoma/*chemistry/diagnosis/pathology
  • Soft Tissue Neoplasms/*chemistry/diagnosis/pathology
  • *Thigh
  • Vimentin/*analysis
Affiliation Not a UNIGE publication
Citation (ISO format)
BOEHNCKE, Wolf-Henning et al. Primary subcutaneous leiomyosarcoma exhibiting the characteristic immunophenotype positive for vimentin and desmin. In: The Journal of dermatologic surgery and oncology, 1994, vol. 20, n° 8, p. 541–543. doi: 10.1111/j.1524-4725.1994.tb00140.x
Identifiers
ISSN of the journal0148-0812
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