Primary subcutaneous leiomyosarcoma exhibiting the characteristic immunophenotype positive for vimentin and desmin
|Published in||Journal of Dermatologic Surgery & Oncology. 1994, vol. 20, no. 8, p. 541-543|
|Abstract||BACKGROUND: Primary subcutaneous leiomyosarcoma is a rare neoplasm composed of plump, elongated spindle cells arranged in interweaving fascicles. OBJECTIVE: Differential diagnosis might be facilitated by the use of immunohistochemistry. METHODS: A case of subcutaneous leiomyosarcoma was investigated histologically on paraffin-embedded tissue and immunohistochemistry was performed following standard procedures. RESULTS: The case reported exhibited light microscopic features and an immunophenotype characteristic of leiomyosarcoma. However, the intermediate filament desmin could only be found on a small number of tumor cells. CONCLUSION: Expression of these markers might vary considerably and immunoperoxidase stainings need to be carefully evaluated. Utilization of several antibodies directed against different desmin epitopes might be advantageous.|
|Keywords||Aged — Desmin/*analysis — Diagnosis, Differential — Female — Humans — Immunohistochemistry — Immunophenotyping — Keratins/analysis — Leiomyosarcoma/*chemistry/diagnosis/pathology — Soft Tissue Neoplasms/*chemistry/diagnosis/pathology — *Thigh — Vimentin/*analysis|
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|BOEHNCKE, Wolf-Henning et al. Primary subcutaneous leiomyosarcoma exhibiting the characteristic immunophenotype positive for vimentin and desmin. In: Journal of Dermatologic Surgery & Oncology, 1994, vol. 20, n° 8, p. 541-543. doi: 10.1111/j.1524-4725.1994.tb00140.x https://archive-ouverte.unige.ch/unige:29696|