Predominant usage of distinct T-cell receptor V beta regions by epidermotropic T cells in psoriasis
|Published in||Experimental dermatology. 1994, vol. 3, no. 4, p. 161-163|
|Abstract||To investigate the role of T cells in psoriasis, we analyzed the T-cell receptor (TCR) repertoire in peripheral blood lymphocytes (PBLs) and in skin lesions of 9 patients with chronic plaque-stage psoriasis by means of immunohistochemistry. An extended panel of monoclonal antibodies detecting 11 different V beta families was employed in this study. In the peripheral blood, no predominant TCR V beta expression was detected and interindividual differences were small. Skin-infiltrating T cells showed only marginal differences in the TCR V beta usage when compared with PBLs. However, in 3 patients the intraepidermal infiltrate comprised up to 40% of T cells expressing a TCR V beta region which was virtually absent in the peripheral blood and the dermal infiltrate. Thus, although the TCR V beta usage of skin-infiltrating T cells showed little difference compared to PBLs, several cases exhibited a significant increase of epidermotrophic T cells using one particular V beta region.|
|Keywords||Epidermis/*immunology — Humans — Psoriasis/*immunology — Receptors, Antigen, T-Cell, alpha-beta/*biosynthesis — T-Lymphocytes/*immunology|
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|BOEHNCKE, Wolf-Henning et al. Predominant usage of distinct T-cell receptor V beta regions by epidermotropic T cells in psoriasis. In: Experimental dermatology, 1994, vol. 3, n° 4, p. 161-163. https://archive-ouverte.unige.ch/unige:29693|