Scientific Article
previous document  unige:29693  next document
add to browser collection

Predominant usage of distinct T-cell receptor V beta regions by epidermotropic T cells in psoriasis

Kuenzlen, C.
Zollner, Thomas Matthias
Mielke, V.
Sterry, Wolfram
Published in Experimental dermatology. 1994, vol. 3, no. 4, p. 161-163
Abstract To investigate the role of T cells in psoriasis, we analyzed the T-cell receptor (TCR) repertoire in peripheral blood lymphocytes (PBLs) and in skin lesions of 9 patients with chronic plaque-stage psoriasis by means of immunohistochemistry. An extended panel of monoclonal antibodies detecting 11 different V beta families was employed in this study. In the peripheral blood, no predominant TCR V beta expression was detected and interindividual differences were small. Skin-infiltrating T cells showed only marginal differences in the TCR V beta usage when compared with PBLs. However, in 3 patients the intraepidermal infiltrate comprised up to 40% of T cells expressing a TCR V beta region which was virtually absent in the peripheral blood and the dermal infiltrate. Thus, although the TCR V beta usage of skin-infiltrating T cells showed little difference compared to PBLs, several cases exhibited a significant increase of epidermotrophic T cells using one particular V beta region.
Keywords Epidermis/*immunologyHumansPsoriasis/*immunologyReceptors, Antigen, T-Cell, alpha-beta/*biosynthesisT-Lymphocytes/*immunology
PMID: 8000704
Full text
This document has no fulltext available yet, but you can contact its author by using the form below.
(ISO format)
BOEHNCKE, Wolf-Henning et al. Predominant usage of distinct T-cell receptor V beta regions by epidermotropic T cells in psoriasis. In: Experimental dermatology, 1994, vol. 3, n° 4, p. 161-163.

483 hits

0 download


Deposited on : 2013-09-20

Export document
Format :
Citation style :