Scientific article

Predominant usage of distinct T-cell receptor V beta regions by epidermotropic T cells in psoriasis

Published inExperimental dermatology, vol. 3, no. 4, p. 161-163
Publication date1994

To investigate the role of T cells in psoriasis, we analyzed the T-cell receptor (TCR) repertoire in peripheral blood lymphocytes (PBLs) and in skin lesions of 9 patients with chronic plaque-stage psoriasis by means of immunohistochemistry. An extended panel of monoclonal antibodies detecting 11 different V beta families was employed in this study. In the peripheral blood, no predominant TCR V beta expression was detected and interindividual differences were small. Skin-infiltrating T cells showed only marginal differences in the TCR V beta usage when compared with PBLs. However, in 3 patients the intraepidermal infiltrate comprised up to 40% of T cells expressing a TCR V beta region which was virtually absent in the peripheral blood and the dermal infiltrate. Thus, although the TCR V beta usage of skin-infiltrating T cells showed little difference compared to PBLs, several cases exhibited a significant increase of epidermotrophic T cells using one particular V beta region.

  • Epidermis/*immunology
  • Humans
  • Psoriasis/*immunology
  • Receptors, Antigen, T-Cell, alpha-beta/*biosynthesis
  • T-Lymphocytes/*immunology
Affiliation Not a UNIGE publication
Citation (ISO format)
BOEHNCKE, Wolf-Henning et al. Predominant usage of distinct T-cell receptor V beta regions by epidermotropic T cells in psoriasis. In: Experimental dermatology, 1994, vol. 3, n° 4, p. 161–163.
ISSN of the journal0906-6705

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