Demonstration of clonal disease in early mycosis fungoides
|Published in||The American Journal of Dermatopathology. 1992, vol. 14, no. 2, p. 95-99|
|Abstract||Cutaneous T-cell lymphomas (CTCLs) are known to show monoclonal T-cell infiltrates late in the course of the disease. However, detection of monoclonal T-cell proliferation in early stages is difficult. To investigate the possibility that clones might appear only as minor subpopulations, we analyzed the proliferative activity of T cells expression certain variable (V) regions of the T-cell receptor (TCR). In biopsy specimens from 27 patients with CTCLs, all T cells expressing the V regions V alpha 2, V beta 5a, V beta 5b, V beta 6, V beta 8 and V beta 12 accounted for less than 5% of the total infiltrate. In the vast majority of the cases, less than 3% of the cells expression one TCR V region proliferated. In one case of mycosis fungoides, however, an epidermotropic clone expressing V beta 8 was detected. This clone was present in two distinct lesions from different anatomic sites and was found in an early relapse 1 year after complete remission following PUVA therapy. The case described here documents the possibility of clonal disease early in the course of mycosis fungoides.|
|Keywords||Aged — Antibodies, Monoclonal — Cell Division — Clone Cells/pathology — Dermatitis, Contact/pathology — Epidermis/pathology — Female — Humans — Immunoenzyme Techniques — Lymphoma, T-Cell, Cutaneous/pathology — Mycosis Fungoides/*pathology — Receptors, Antigen, T-Cell/*analysis — Skin Neoplasms/*pathology — T-Lymphocyte Subsets/*pathology|
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|BOEHNCKE, Wolf-Henning et al. Demonstration of clonal disease in early mycosis fungoides. In: The American Journal of Dermatopathology, 1992, vol. 14, n° 2, p. 95-99. https://archive-ouverte.unige.ch/unige:29692|