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Title

Demonstration of clonal disease in early mycosis fungoides

Authors
Krettek, S.
Parwaresch, M. R.
Sterry, Wolfram
Published in The American Journal of Dermatopathology. 1992, vol. 14, no. 2, p. 95-99
Abstract Cutaneous T-cell lymphomas (CTCLs) are known to show monoclonal T-cell infiltrates late in the course of the disease. However, detection of monoclonal T-cell proliferation in early stages is difficult. To investigate the possibility that clones might appear only as minor subpopulations, we analyzed the proliferative activity of T cells expression certain variable (V) regions of the T-cell receptor (TCR). In biopsy specimens from 27 patients with CTCLs, all T cells expressing the V regions V alpha 2, V beta 5a, V beta 5b, V beta 6, V beta 8 and V beta 12 accounted for less than 5% of the total infiltrate. In the vast majority of the cases, less than 3% of the cells expression one TCR V region proliferated. In one case of mycosis fungoides, however, an epidermotropic clone expressing V beta 8 was detected. This clone was present in two distinct lesions from different anatomic sites and was found in an early relapse 1 year after complete remission following PUVA therapy. The case described here documents the possibility of clonal disease early in the course of mycosis fungoides.
Keywords AgedAntibodies, MonoclonalCell DivisionClone Cells/pathologyDermatitis, Contact/pathologyEpidermis/pathologyFemaleHumansImmunoenzyme TechniquesLymphoma, T-Cell, Cutaneous/pathologyMycosis Fungoides/*pathologyReceptors, Antigen, T-Cell/*analysisSkin Neoplasms/*pathologyT-Lymphocyte Subsets/*pathology
Identifiers
PMID: 1566982
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BOEHNCKE, Wolf-Henning et al. Demonstration of clonal disease in early mycosis fungoides. In: The American Journal of Dermatopathology, 1992, vol. 14, n° 2, p. 95-99. https://archive-ouverte.unige.ch/unige:29692

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Deposited on : 2013-09-20

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