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Title

A majority of proliferating T cells in cutaneous malignant T cell lymphomas may lack the high affinity IL-2 receptor (CD25)

Authors
Gerdes, J.
Wiese, M.
Kaltoft, K.
Sterry, Wolfram
Published in Archives of Dermatological Research. 1993, vol. 285, no. 3, p. 127-130
Abstract IL-2 is a major growth factor for all T-cell subsets acting via a specific membrane receptor. To investigate its role in the pathogenesis of cutaneous T-cell lymphomas (CTCLs), we analysed the expression of high-affinity IL-2 receptors (IL-2Rs) on proliferating cells in these disorders. We showed by immunohistochemical double staining that most cycling cells do not express high-affinity IL-2Rs. Four T-cell lines were established from patients with CTCLs. Two lines required both IL-2 and IL-4 for growth, one line required IL-2 and one line IL-4 alone. The last of these lacked expression of the IL-2R alpha-chain. Thus, IL-2 may not be the only, or the most important, growth stimulus in CTCLs and reactive skin infiltrates. T helper cells, which dominated the infiltrate, might represent TH2 cells.
Keywords Biological Markers/chemistryCell Division/immunologyHumansKi-67 AntigenLymphoma, T-Cell, Cutaneous/*immunology/pathologyNeoplasm Proteins/analysisNuclear Proteins/analysisReceptors, Interleukin-2/*analysisT-Lymphocytes/cytology/*immunology
Identifiers
PMID: 8503692
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BOEHNCKE, Wolf-Henning et al. A majority of proliferating T cells in cutaneous malignant T cell lymphomas may lack the high affinity IL-2 receptor (CD25). In: Archives of Dermatological Research, 1993, vol. 285, n° 3, p. 127-130. https://archive-ouverte.unige.ch/unige:29686

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Deposited on : 2013-09-20

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