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Scientific article
English

A majority of proliferating T cells in cutaneous malignant T cell lymphomas may lack the high affinity IL-2 receptor (CD25)

Published inArchives of dermatological research, vol. 285, no. 3, p. 127-130
Publication date1993
Abstract

IL-2 is a major growth factor for all T-cell subsets acting via a specific membrane receptor. To investigate its role in the pathogenesis of cutaneous T-cell lymphomas (CTCLs), we analysed the expression of high-affinity IL-2 receptors (IL-2Rs) on proliferating cells in these disorders. We showed by immunohistochemical double staining that most cycling cells do not express high-affinity IL-2Rs. Four T-cell lines were established from patients with CTCLs. Two lines required both IL-2 and IL-4 for growth, one line required IL-2 and one line IL-4 alone. The last of these lacked expression of the IL-2R alpha-chain. Thus, IL-2 may not be the only, or the most important, growth stimulus in CTCLs and reactive skin infiltrates. T helper cells, which dominated the infiltrate, might represent TH2 cells.

Keywords
  • Biological Markers/chemistry
  • Cell Division/immunology
  • Humans
  • Ki-67 Antigen
  • Lymphoma, T-Cell, Cutaneous/*immunology/pathology
  • Neoplasm Proteins/analysis
  • Nuclear Proteins/analysis
  • Receptors, Interleukin-2/*analysis
  • T-Lymphocytes/cytology/*immunology
Affiliation Not a UNIGE publication
Citation (ISO format)
BOEHNCKE, Wolf-Henning et al. A majority of proliferating T cells in cutaneous malignant T cell lymphomas may lack the high affinity IL-2 receptor (CD25). In: Archives of dermatological research, 1993, vol. 285, n° 3, p. 127–130. doi: 10.1007/bf01112913
Identifiers
ISSN of the journal0340-3696
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