This study, which included 45 persons suffering from schizophrenia, had four aims: 1. to characterize difficulties patients have with daily-life activities using the Profinteg questionnaire; 2. to identify the cognitive processes that are predictive of the total level of difficulty; 3. to identify the cognitive processes involved in a multi-tasking activity assessed in real situation: the meeting preparation task; 4. to characterize the intra- and inter-individual variability of performances in cognitive tests and functional task. The results indicated that inhibition plays an important role in a large number of meeting initiation difficulties in the Profinteg questionnaire. Concerning the meeting preparation task, the assessed cognitive functions explained 26 to 43% of the variance in several functional measures: the index of goal achievement, the index of prospective memory, the number of errors and the number of times a rule was not respected. Furthermore, flexibility and processing speed were found to be the best predictors of the task. Finally, various cognitive and functional profiles were observed. These results suggest the necessity, on an individual level, of putting together both cognitive and functional capacities in order to establish a personalized cognitive remediation program.