en
Scientific article
English

Staging colorectal cancer with the TNM 7(th): the presumption of innocence when applying the M category

Published inWorld journal of gastroenterology, vol. 19, no. 8, p. 1152-1157
Publication date2013
Abstract

One of the main changes of the current TNM-7 is the elimination of the category MX, since it has been a source of ambiguity and misinterpretation, especially by pathologists. Therefore the ultimate staging would be better performed by the patient's clinician who can classify the disease M0 (no distant metastasis) or M1 (presence of distant metastasis), having access to the completeness of data resulting from clinical examination, imaging workup and pathology report. However this important change doesn't take into account the diagnostic value and the challenge of small indeterminate visceral lesions encountered, in particular, during radiological staging of patients with colorectal cancer. In this article the diagnosis of these lesions with multiple imaging modalities, their frequency, significance and relevance to staging and disease management are described in a multidisciplinary way. In particular the interplay between clinical, radiological and pathological staging, which are usually conducted independently, is discussed. The integrated approach shows that there are both advantages and disadvantages to abandoning the MX category. To avoid ambiguity arising both by applying and interpreting MX category for stage assigning, its abandoning seems reasonable. The recognition of the importance of small lesion characterization raises the need for applying a separate category; therefore a proposal for their categorization is put forward. By using the proposed categorization the lack of consideration for indeterminate visceral lesions with the current staging system will be overcome, also optimizing tailored follow-up.

Citation (ISO format)
PUPPA, Giacomo et al. Staging colorectal cancer with the TNM 7(th): the presumption of innocence when applying the M category. In: World journal of gastroenterology, 2013, vol. 19, n° 8, p. 1152–1157. doi: 10.3748/wjg.v19.i8.1152
Main files (1)
Article (Accepted version)
accessLevelRestricted
Identifiers
ISSN of the journal1007-9327
569views
0downloads

Technical informations

Creation08/13/2013 3:42:00 PM
First validation08/13/2013 3:42:00 PM
Update time03/14/2023 8:23:21 PM
Status update03/14/2023 8:23:21 PM
Last indexation01/16/2024 2:04:26 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack