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Title

Staging colorectal cancer with the TNM 7(th): the presumption of innocence when applying the M category
Authors
Puppa, Giacomo
Poston, Graeme
Jess, Per
Nash, Guy F
Coenegrachts, Kenneth
Stang, Axel
Published in World Journal of Gastroenterology. 2013, vol. 19, no. 8, p. 1152-7
Abstract One of the main changes of the current TNM-7 is the elimination of the category MX, since it has been a source of ambiguity and misinterpretation, especially by pathologists. Therefore the ultimate staging would be better performed by the patient's clinician who can classify the disease M0 (no distant metastasis) or M1 (presence of distant metastasis), having access to the completeness of data resulting from clinical examination, imaging workup and pathology report. However this important change doesn't take into account the diagnostic value and the challenge of small indeterminate visceral lesions encountered, in particular, during radiological staging of patients with colorectal cancer. In this article the diagnosis of these lesions with multiple imaging modalities, their frequency, significance and relevance to staging and disease management are described in a multidisciplinary way. In particular the interplay between clinical, radiological and pathological staging, which are usually conducted independently, is discussed. The integrated approach shows that there are both advantages and disadvantages to abandoning the MX category. To avoid ambiguity arising both by applying and interpreting MX category for stage assigning, its abandoning seems reasonable. The recognition of the importance of small lesion characterization raises the need for applying a separate category; therefore a proposal for their categorization is put forward. By using the proposed categorization the lack of consideration for indeterminate visceral lesions with the current staging system will be overcome, also optimizing tailored follow-up.
Identifiers
PMID: 23483791
Full text
Article (Author postprint) (995 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research group Métastases du foie (657)
Citation
(ISO format) 		PUPPA, Giacomo et al. Staging colorectal cancer with the TNM 7(th): the presumption of innocence when applying the M category. In: World Journal of Gastroenterology, 2013, vol. 19, n° 8, p. 1152-7. https://archive-ouverte.unige.ch/unige:29466

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Deposited on : 2013-08-28

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