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Title

Pathophysiology and treatment of secondary and tertiary hyperparathyroidism

Authors
Evenepoel, Pieter
Published in Oertli, D. & Udelsman, R. Surgery of the thyroid and parathyroid glands. Berlin: Springer. 2012, p. 517-536
Abstract Serum parathyroid hormone (PTH) levels start to rise once the glomerular filtration rate falls below 60 ml/min with secondary hyperparathyroidism (2HPTH), becoming an almost universal complication in dialysis dependent chronic kidney disease (CKD). A better knowledge of the biological functions of the calcium-sensing receptor (CaSR) and the vitamin D receptor (VDR), and especially the recent discovery of fibroblast growth factor 23 (FGF-23) and the elucidation of its function as a phosphaturic and 1,25(OH)2VitD counterregulatory hormone have provided a new conceptual framework for the understanding of the pathogenesis of 2HPTH.
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ISBN: 978-3-642-23459-0
Full text
Book chapter (Published version) (7.7 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Chirurgie thoracique et chirurgie endocrinologique (573)
Mésothéliome pleural malin (944)
Citation
(ISO format)
TRIPONEZ, Frédéric, EVENEPOEL, Pieter. Pathophysiology and treatment of secondary and tertiary hyperparathyroidism. In: Oertli, D. & Udelsman, R. (Ed.). Surgery of the thyroid and parathyroid glands. Berlin : Springer, 2012. p. 517-536. https://archive-ouverte.unige.ch/unige:29451

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Deposited on : 2013-08-27

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