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Title

Fine-Needle Aspiration of Primary Langerhans Cell Histiocytosis of the Thyroid Gland, a Potential Mimic of Papillary Thyroid Carcinoma

Authors
Sauder, Kenan J
Cibas, Edmund S
Faquin, William C
Published in Acta Cytologica. 2013, vol. 57, no. 4, p. 406-412
Abstract Background: The clinical presentation of Langerhans cell histiocytosis (LCH) as a primary solitary nodule in the thyroid gland is rare. As a result, there are few reports of its cytologic features in thyroid aspirates where it can pose a diagnostic pitfall. Case and Conclusion: To foster familiarity with its cytomorphology, we report the fine-needle aspiration biopsy (FNAB) findings of 3 specimens from 2 patients with LCH presenting as a solitary thyroid nodule. All aspirates contained numerous dispersed cells with prominent nuclear grooves, and the background showed a mixed pattern of chronic inflammation including scattered eosinophils. The aspirate from patient 1 raised a differential diagnosis that included chronic lymphocytic thyroiditis and a thyroglossal duct cyst, while the aspirate from patient 2 was interpreted as 'suspicious for papillary thyroid carcinoma'. The diagnosis of LCH was confirmed in both patients after lobectomy and immunohistochemical studies that revealed positive reactivity for CD1a and S-100. LCH of the thyroid gland is rare and can pose significant diagnostic challenges, but increased familiarity with its characteristic cytomorphology can help in avoiding diagnostic pitfalls.
Identifiers
PMID: 23860349
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Research group Groupe Pache Jean-Claude (pathologie clinique) (658)
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PUSZTASZERI, Marc et al. Fine-Needle Aspiration of Primary Langerhans Cell Histiocytosis of the Thyroid Gland, a Potential Mimic of Papillary Thyroid Carcinoma. In: Acta Cytologica, 2013, vol. 57, n° 4, p. 406-412. https://archive-ouverte.unige.ch/unige:29357

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Deposited on : 2013-08-19

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